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    The hydrolytic behavior of N,N’-(dimethylamino) ethyl acrylate-functionalized polymeric stars

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    Publication date
    2017-03-17
    Author
    Rolph, M.S.
    Pitto-Barry, Anaïs
    O'Reilly, R.K.
    Keyword
    RAFT polymerisation; Cross-linked polymeric stars
    Rights
    © The Royal Society of Chemistry 2017. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)
    Peer-Reviewed
    Yes
    
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    Abstract
    Well-defined N,N’-(dimethylamino)ethyl acrylate (DMAEA) functionalized polymeric stars have been synthesized via an arm-first approach. Utilizing reversible addition–fragmentation chain transfer polymerization, linear homopolymers (PEGA, PHEA) were chain extended with DMAEA and a divinyl crosslinker to produce a series of crosslinked polymeric stars. These stars were characterized using a range of techniques including NMR, SEC, DLS and TEM analysis. The hydrolytic behavior of the DMAEA when tethered within a micellar core was investigated by1 H NMR spectroscopy and was found to be strongly dependent on temperature. At elevated temperatures either a higher crosslinking density or a longer arm length was found to offer greater protection to the amine resulting in slower hydrolysis, with hydrolysis found to level off at a lower final percentage hydrolysis. In contrast, the composition and nature of the arm was found to have little impact on the hydrolysis, with the same trends relating to the effect of temperature and crosslinking density observed with a linear (HEA) and a brush (PEGA) arm. Additionally, the release of DMAE from the polymeric stars was successfully confirmed through the use of an enzymatic assay, producing a concentration of DMAE in good agreement with the theoretical concentration based on the 1H NMR spectroscopic analysis.
    URI
    http://hdl.handle.net/10454/15422
    Version
    Published version
    Citation
    Rolph MS, Pitto-Barry A and O’Reilly RK (2017) The hydrolytic behaviour of N,N’- (dimethylamino)ethyl acrylate-functionalized polymeric stars. Polymer Chemistry. 8(34): 5060- 5070.
    Link to publisher’s version
    http://dx.doi.org/10.1039/c7py00219j
    Type
    Article
    Collections
    Life Sciences Publications

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