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    Use of complementary nucleobase-containing synthetic polymers to prepare complex self-assembled morphologies in water

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    Pitto-Barry_Polymer_Chemistry.pdf (1.969Mb)
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    Publication date
    2016-04-28
    Author
    Kang, Y.
    Pitto-Barry, Anaïs
    Rolph, M.S.
    Hua, Z.
    Hands-Portman, I.
    Kirby, N.
    O'Reilly, R.K.
    Keyword
    Nucleobase-containing polymers; RAFT polymerisation; Self-assembly
    Rights
    © The Royal Society of Chemistry 2016. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)
    Peer-Reviewed
    Yes
    
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    Abstract
    Amphiphilic nucleobase-containing block copolymers with poly(oligo(ethylene glycol) methyl ether methacrylate) as the hydrophilic block and nucleobase-containing blocks as the hydrophobic segments were successfully synthesized using RAFT polymerization and then self-assembled via solvent switch in aqueous solutions. Effects of the common solvent on the resultant morphologies of the adenine (A) and thymine (T) homopolymers, and A/T copolymer blocks and blends were investigated. These studies highlighted that depending on the identity of the common solvent, DMF or DMSO, spherical micelles or bicontinuous micelles were obtained. We propose that this is due to the presence of A–T interactions playing a key role in the morphology and stability of the resultant nanoparticles, which resulted in a distinct system compared to individual adenine or thymine polymers. Finally, the effects of annealing on the self-assemblies were explored. It was found that annealing could lead to better-defined spherical micelles and induce a morphology transition from bicontinuous micelles to onion-like vesicles, which was considered to occur due to a structural rearrangement of complementary nucleobase interactions resulting from the annealing process.
    URI
    http://hdl.handle.net/10454/15420
    Version
    Published version
    Citation
    Kang Y, Pitto-Barry A, Rolph MS et al (2016) Use of complementary nucleobasecontaining synthetic polymers to prepare complex self-assembled morphologies in water. Polymer Chemistry. 7(16): 2836-2846.
    Link to publisher’s version
    http://dx.doi.org/10.1039/C6PY00263C
    Type
    Article
    Collections
    Life Sciences Publications

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