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dc.contributor.authorWilliams, R.J.*
dc.contributor.authorPitto-Barry, Anaïs*
dc.contributor.authorKirby, N.*
dc.contributor.authorDove, A.P.*
dc.contributor.authorO'Reilly, R.K.*
dc.date.accessioned2018-03-29T15:21:12Z
dc.date.available2018-03-29T15:21:12Z
dc.date.issued2016-04-12
dc.identifier.citationWilliams RJ, Pitto-Barry A, Kirby N, Dove AP and O'Reilly RK (2016) Cyclic graft copolymer unimolecular micelles : effects of cyclization on particle morphology and thermoresponsive behavior. Macromolecules. 49(7): 2802-2813.en_US
dc.identifier.urihttp://hdl.handle.net/10454/15391
dc.descriptionyesen_US
dc.description.abstractThe synthesis of cyclic amphiphilic graft copolymers with a hydrophobic polycarbonate backbone and hydrophilic poly(N-acryloylmorpholine) (PNAM) side arms via a combination of ring-opening polymerization (ROP), cyclization via copper-catalyzed azide–alkyne cycloaddition (CuAAC), and reversible addition–fragmentation chain transfer (RAFT) polymerization is reported. The ability of these cyclic graft copolymers to form unimolecular micelles in water is explored using a combination of light scattering, small-angle X-ray scattering (SAXS), and cryogenic transmission electron microscopy (cryoTEM) analyses, where particle size was found to increase with increasing PNAM arm length. Further analysis revealed differences in the solution conformations, loading capabilities, and morphologies of the cyclic graft copolymers in comparison to equivalent linear graft copolymer unimolecular micelle analogues. Furthermore, the cyclic and linear graft copolymers were found to exhibit significantly different cloud point temperatures. This study highlights how subtle changes in polymer architecture (linear graft copolymer versus cyclic graft copolymer) can dramatically influence a polymer’s nanostructure and its properties.en_US
dc.description.sponsorshipRoyal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC)en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1021/acs.macromol.5b02710en_US
dc.rights© 2016 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License.en_US
dc.subjectCyclic polymers; Copper-catalysed azide-alkyne cycloaddition; RAFT polymerisation; Unimolecular micelles; Self-assembly; Linear polymers; Graft copolymersen_US
dc.titleCyclic graft copolymer unimolecular micelles : effects of cyclization on particle morphology and thermoresponsive behavioren_US
dc.status.refereedYesen_US
dc.date.application2016-03-17
dc.typeArticleen_US
dc.type.versionPublished versionen_US


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