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dc.contributor.advisorForbes, Robert T.
dc.contributor.advisorHulse, W.L.
dc.contributor.authorSeymour, Louise
dc.date.accessioned2018-03-26T13:40:49Z
dc.date.available2018-03-26T13:40:49Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10454/15321
dc.description.abstractThe majority of therapeutic pharmaceutical formulations are presented in the solid form. Moisture is able to play an important role in the functional performance of pharmaceutical solids. Moisture profiling is able to provide novel information with regards to the behaviour of moisture within materials using equilibrium relative humidity as a measurement. The hypothesis investigated explores the changes in equilibrium relative humidity of pharmaceutical material induced by physical, chemical or storage conditions, these are able to be monitored using the innovative moisture profiler system. The aims within this were to primarily validate the moisture profiler and secondly evaluate the effects of moisture on physical forms and with respect to effects of compaction, finally this was compared to conventional characterisation methods. Preliminary explorations were conducted in order to assess the validity of the moisture profiler, from this lactose was selected as a suitable pharmaceutical material for further work. Processing effects were then examined, firstly storage at elevated relative humidity of different forms of lactose were explored, and this was carried out with supplementary analysis. Secondly the effects of tabletting were explored, different compaction forces were investigated to observe if this had any notable effects on equilibrium relative humidity of the different lactose forms. Finally subsequent storage of the compacts were examined in order to explore if there were any changes in the equilibrium relative humidity.en_US
dc.description.sponsorshipEPSRC and Reckitt Benckiseren_US
dc.language.isoenen_US
dc.rights<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.en_US
dc.subjectMoisture profiling; Equilibrium relative humidity; Compaction; Storage stability; Lactose physical forms; Solid state properties; Thermal propertiesen_US
dc.titleThe role of moisture profiling towards understanding pharmaceutical solid state functionality. Validation and the application of a moisture profiling analytical tool for investigation into the characterisation of and prediction of the effects of compaction and storage on different lactose physical formsen_US
dc.type.qualificationleveldoctoralen_US
dc.publisher.institutionUniversity of Bradfordeng
dc.publisher.departmentSchool of Pharmacy, Faculty of Life Sciencesen_US
dc.typeThesiseng
dc.type.qualificationnamePhDen_US
dc.date.EndofEmbargo2020-10-26
dc.date.awarded2015
dc.description.publicnotesThe full-text will be available at the end of the embargo, 26th Oct 2020en


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