Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology

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Publication date
2018
End of Embargo
2019-03-13
Author
Korde, Sachin A.
Pagire, Sudhir K.
Pan, H.
Seaton, Colin C.
Kelly, Adrian L.
Chen, Y.
Wang, Q.
Coates, Philip D.
Paradkar, Anant R.
Keyword
Solid state shear milling (S3M); Polymer-assisted cocrystallization technique; Continuous manufacturing; Pharmaceutical cocrystals.
Rights
© 2018 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b01733.
Peer-Reviewed
yes

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Abstract
Solid state shear milling (S3M) is reported as a scalable, continuous, polymer-assisted cocrystallization technique. A specially designed milling pan was employed to provide high levels of applied shear, and the addition of a polymeric processing aid enabled generation of high stress fields. Carbamazepine–salicylic acid cocrystals were produced with 5–25 wt % of poly(ethylene oxide) (PEO). A systematic study was carried out to understand the effect of process variables on properties and performance of the cocrystals. S3M offers an important new route for continuous manufacturing of pharmaceutical cocrystals.
URI
http://hdl.handle.net/10454/15301
Version
Accepted Manuscript
Citation
Korde S, Pagire S, Pan H, Seaton C, Kelly A, Chen Y, Wang Q, Coates P and Paradkar A (2018) Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology. Crystal Growth & Design. Online before print.
Link to publisher’s version
https://doi.org/10.1021/acs.cgd.7b01733
Type
Article
Notes
The full text will be available at the end of the publisher's embargo, 13th Mar 2019.
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