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    Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology

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    Publication date
    2018
    End of Embargo
    2019-03-13
    Author
    Korde, Sachin A.
    Pagire, Sudhir K.
    Pan, H.
    Seaton, Colin C.
    Kelly, Adrian L.
    Chen, Y.
    Wang, Q.
    Coates, Philip D.
    Paradkar, Anant R.
    Keyword
    Solid state shear milling (S3M); Polymer-assisted cocrystallization technique; Continuous manufacturing; Pharmaceutical cocrystals.
    Rights
    © 2018 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.7b01733.
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Solid state shear milling (S3M) is reported as a scalable, continuous, polymer-assisted cocrystallization technique. A specially designed milling pan was employed to provide high levels of applied shear, and the addition of a polymeric processing aid enabled generation of high stress fields. Carbamazepine–salicylic acid cocrystals were produced with 5–25 wt % of poly(ethylene oxide) (PEO). A systematic study was carried out to understand the effect of process variables on properties and performance of the cocrystals. S3M offers an important new route for continuous manufacturing of pharmaceutical cocrystals.
    URI
    http://hdl.handle.net/10454/15301
    Version
    Accepted Manuscript
    Citation
    Korde S, Pagire S, Pan H, Seaton C, Kelly A, Chen Y, Wang Q, Coates P and Paradkar A (2018) Continuous Manufacturing of Cocrystals Using Solid State Shear Milling Technology. Crystal Growth & Design. Online before print.
    Link to publisher’s version
    https://doi.org/10.1021/acs.cgd.7b01733
    Type
    Article
    Notes
    The full text will be available at the end of the publisher's embargo, 13th Mar 2019.
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    Life Sciences Publications

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