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    AuthorFenton, D.A. (1)Leung, Man Ching (1)Sutton, Chris W. (1)Tobin, Desmond J. (1)Subject
    Adult (1)
    Alopecia Areata; Blood; Immunology (1)
    Autoantigens; Analysis (1)
    Female (1)
    Fluorescent antibody technique; Indirect (1)Hair follicle; Pathology (1)Humans (1)Intermediate filament proteins (1)Keratin-16 (1)Male (1)View MoreDate Issued2010 (1)

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    Trichohyalin is a potential major autoantigen in human alopecia areata

    Leung, Man Ching; Sutton, Chris W.; Fenton, D.A.; Tobin, Desmond J. (2010)
    Several lines of evidence support an autoimmune basis for alopecia areata (AA), a common putative autoimmune hair loss disorder. However, definitive support is lacking largely because the identity of hair follicle (HF) autoantigen(s) involved in its pathogenesis remains unknown. Here, we isolated AA-reactive HF-specific antigens from normal human scalp anagen HF extracts by immunoprecipitation using serum antibodies from 10 AA patients. Samples were analyzed by LC-MALDI-TOF/TOF mass spectrometry, which indicated strong reactivity to the hair growth phase-specific structural protein trichohyalin in all AA sera. Keratin 16 (K16) was also identified as another potential AA-relevant target HF antigen. Double immunofluorescence studies using AA (and control sera) together with a monoclonal antibody to trichohyalin revealed that AA sera contained immunoreactivity that colocalized with trichohyalin in the growth phase-specific inner root sheath of HF. Furthermore, a partial colocalization of AA serum reactivity with anti-K16 antibody was observed in the outer root sheath of the HF. In summary, this study supports the involvement of an immune response to anagen-specific HFs antigens in AA and specifically suggests that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder.
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