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    AuthorBrown, S.D.M. (1)D'Adamo, M.C. (1)Imbrici, P. (1)Pessia, M. (1)Shang, Lijun (1)Tucker, S.J. (1)Subject
    ; Animals (1)
    ; Carbon dioxide (1)
    ; Electric conductivity (1)
    ; Female (1); Gene deletion (1); Hydrogen-ion concentration (1); Locus coeruleus (1); Male (1); Mice; Inbred C57BL (1)
    ; Neurons (1)
    View MoreDate Issued
    2011 (1)

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    Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity

    D'Adamo, M.C.; Shang, Lijun; Imbrici, P.; Brown, S.D.M.; Pessia, M.; Tucker, S.J. (2011)
    The molecular identity of ion channels which confer PCO(2)/pH sensitivity in the brain is unclear. Heteromeric Kir4.1/Kir5.1 channels are highly sensitive to inhibition by intracellular pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory control, including the locus coeruleus. This has therefore led to a proposed role for these channels in neuronal CO(2) chemosensitivity. To examine this, we generated mutant mice lacking the Kir5.1 (Kcnj16) gene. We show that although locus coeruleus neurons from Kcnj16((+/+)) mice rapidly respond to cytoplasmic alkalinization and acidification, those from Kcnj16((-/-)) mice display a dramatically reduced and delayed response. These results identify Kir5.1 as an important determinant of PCO(2)/pH sensitivity in locus coeruleus neurons and suggest that Kir5.1 may be involved in the response to hypercapnic acidosis.
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