BRADFORD SCHOLARS

    • Sign in
    Search 
    •   Bradford Scholars
    • Life Sciences
    • Search
    •   Bradford Scholars
    • Life Sciences
    • Search
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CommunityAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    Filter by Category

    AuthorArthur, J.S. (1)Corrêa, Sonia A.L. (1)Frenguelli, B.G. (1)Hunter, C.J. (1)Martin, K.J. (1)McKelvey, K. (1)McKenzie, C. (1)Morris, R.G. (1)Palygin, O. (1)Pankratov, Y. (1)View MoreSubject; Animals (1); Brain-derived neurotrophic factor (1)
    ; Cells (1)
    ; Cytoskeletal proteins (1); Dendritic spines (1); Environment (1)
    ; Enzyme inhibitors (1)
    ; Excitatory postsynaptic potentials (1)
    ; Female (1)
    ; Gene expression regulation (1)View MoreDate Issued2012 (1)

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Display statistics
     

    Search

    Show Advanced FiltersHide Advanced Filters

    Filters

    Now showing items 1-1 of 1

    • List view
    • Grid view
    • Sort Options:
    • Relevance
    • Title Asc
    • Title Desc
    • Issue Date Asc
    • Issue Date Desc
    • Results Per Page:
    • 5
    • 10
    • 20
    • 40
    • 60
    • 80
    • 100

    • 1CSV
    • 1RefMan
    • 1EndNote
    • 1BibTex
    • Selective Export
    • Select All
    • Help
    Thumbnail

    MSK1 regulates homeostatic and experience-dependent synaptic plasticity

    Corrêa, Sonia A.L.; Hunter, C.J.; Palygin, O.; Wauters, S.C.; Martin, K.J.; McKenzie, C.; McKelvey, K.; Morris, R.G.; Pankratov, Y.; Arthur, J.S.; et al. (2012)
    The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response to environmental influences, the cellular and molecular mechanisms underlying synaptic adaptation are far from clear. Brain-derived neurotrophic factor (BDNF) is a prime initiator of structural and functional synaptic adaptation. However, the signaling cascade activated by BDNF to initiate these adaptive changes has not been elucidated. We have previously shown that BDNF activates mitogen- and stress-activated kinase 1 (MSK1), which regulates gene transcription via the phosphorylation of both CREB and histone H3. Using mice with a kinase-dead knock-in mutation of MSK1, we now show that MSK1 is necessary for the upregulation of synaptic strength in response to environmental enrichment in vivo. Furthermore, neurons from MSK1 kinase-dead mice failed to show scaling of synaptic transmission in response to activity deprivation in vitro, a deficit that could be rescued by reintroduction of wild-type MSK1. We also show that MSK1 forms part of a BDNF- and MAPK-dependent signaling cascade required for homeostatic synaptic scaling, which likely resides in the ability of MSK1 to regulate cell surface GluA1 expression via the induction of Arc/Arg3.1. These results demonstrate that MSK1 is an integral part of a signaling pathway that underlies the adaptive response to synaptic and environmental experience. MSK1 may thus act as a key homeostat in the activity- and experience-dependent regulation of synaptic strength.
    DSpace software (copyright © 2002 - 2019)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.