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    AuthorBarry, Nicolas P.E. (1)Green, S. (1)Kirby, N. (1)Phoenix, B. (1)
    Pitto-Barry, Anaïs (1)
    Romero-Canelón, I. (1)Sadler, P.J. (1)Soldevila-Barreda, J.J. (1)Tran, J. (1)Subject
    Arene ruthenium; Carborane; Pluronic; Micelles; Boron neutron capture therapy (1)
    View MoreDate Issued2015 (1)

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    Arene ruthenium dithiolato-carborane complexes for boron neutron capture theory (BNCT)

    Romero-Canelón, I.; Phoenix, B.; Pitto-Barry, Anaïs; Tran, J.; Soldevila-Barreda, J.J.; Kirby, N.; Green, S.; Sadler, P.J.; Barry, Nicolas P.E. (2015)
    We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolatoecarborane complex [Ru(p-cymene) (1,2- dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 coreeshell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 mM and 0.17 mM, respectively) and cisplatinresistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 mM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5 ), and was sensitive to neutron irradiation in A2780 cells (1.4 more potent upon irradiation compared to non-irradiation).
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