Browsing Life Sciences by Author "Waddell, P.G."
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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cellsNigam, S.; Burke, B.P.; Davies, L.H.; Domarkas, J.; Wallis, J.F.; Waddell, P.G.; Waby, Jennifer S.; Benoit, D.M.; Seymour, A.-M.; Cawthorne, C.; et al. (2016-05)The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.