Browsing Life Sciences by Author "Tsatmali, Marina"
Prostaglandin production by melanocytic cells and the effect of a-melanocyte stimulating hormoneNicolaou, Anna; Estdale, Siân E.; Tsatmali, Marina; Herrero, Daniel Pascual; Thody, Anthony J. (2004)Prostaglandins are potent mediators of the inﬂam-matory response and are also involved in cancer development. In this study, we show that human melanocytes and FM55 melanoma cells express cyclooxygenase-1 and -2 (COX-1 and-2) and thus have the capability to produce prostaglandins. TheFM55 cells produced predominantly PGE2and PGF2a, whereas the HaCaT keratinocyte cell line produced mainly PGE2. The anti-inﬂammatory peptide, a-melanocyte stimulating hormone(a-MSH), reduced prostaglandin production in FM55 and HaCaT cells and reversed the eﬀect of the pro-inﬂammatory cytokine TNF-a in the former. These results indicate that melanocytes produce prostaglandins and that a-MSH, by inhibiting this response, may play an important role in regulating inﬂammatory responses in the skin.