Browsing Life Sciences by Author "Daga, M."
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinitySantos, Ana R.N.; Sheldrake, Helen M.; Ibrahim, Ali I.M.; Danta, Chhanda C.; Bonanni, D.; Daga, M.; Oliaro-Bosso, s.; Boschi, D.; Lolli, M.L.; Pors, Klaus (2019-01)Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.