• Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency

      Crawford, Deborah E.; Miskimmin, C.K.; Cahir, J.; James, S.L. (2017-11)
      Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.