• Probing linker design in citric acid-ciprofloxacin conjugates

      Milner, S.J.; Snelling, Anna M.; Kerr, Kevin G.; Abd-El-Aziz, A.; Thomas, G.H.; Hubbard, R.E.; Routledge, A.; Duhme-Klair, A-K. (2014)
      A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.