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    An update on genomic-guided therapies for pediatric solid tumors

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    Lee_Future_Oncology.pdf (2.141Mb)
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    Publication date
    2017-06
    Author
    Tsui, P.C.
    Lee, Stephanie
    Liu, Z.W.Y.
    Ip, L.R.H.
    Piao, W.
    Chiang, A.K.S.
    Lui, V.W.Y.
    Keyword
    Clinical trials on targeted therapies; Pediatric solid tumors; Whole-exome sequencing
    Rights
    © 2017 Future Medicine Ltd. Reproduced in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Currently, out of the 82 US FDA-approved targeted therapies for adult cancer treatments, only three are approved for use in children irrespective of their genomic status. Apart from leukemia, only a handful of genomic-based trials involving children with solid tumors are ongoing. Emerging genomic data for pediatric solid tumors may facilitate the development of precision medicine in pediatric patients. Here, we provide an up-to-date review of all reported genomic aberrations in the eight most common pediatric solid tumors with whole-exome sequencing or whole-genome sequencing data (from cBioPortal database, Pediatric Cancer Genome Project, Therapeutically Applicable Research to Generate Effective Treatments) and additional non-whole-exome sequencing studies. Potential druggable events are highlighted and discussed so as to facilitate preclinical and clinical research in this area.
    URI
    http://hdl.handle.net/10454/14823
    Version
    Accepted Manuscript
    Citation
    Tsui PC, Lee Y-F, Liu ZWY et al (2017) An update on genomic-guided therapies for pediatric solid tumors. Future Oncology. 13(15): 1345-1358.
    Link to publisher’s version
    https://doi.org/10.2217/fon-2017-0003
    Type
    Article
    Collections
    Life Sciences Publications

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