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dc.contributor.authorAshby, R.L.*
dc.contributor.authorWard, K.A.*
dc.contributor.authorRoberts, S.A.*
dc.contributor.authorEdwards, Lisa*
dc.contributor.authorMughal, M.Z.*
dc.contributor.authorAdams, Jenny E.*
dc.date.accessioned2018-01-17T15:24:40Z
dc.date.available2018-01-17T15:24:40Z
dc.date.issued2009-08
dc.identifier.citationAshby RL, Ward KA, Roberts SA et al (2009) A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years. Osteoporosis International. 20(8): 1337-1346.en_US
dc.identifier.urihttp://hdl.handle.net/10454/14542
dc.descriptionNoen_US
dc.description.abstractSummary We have produced paediatric reference data for forearm sites using the Stratec XCT-2000 peripheral quantitative computed tomography scanner. These data are intended for clinical and research use and will assist in the interpretation of bone mineral density and bone geometric parameters at the distal and mid-shaft radius in children and young adults aged between 6–19 years. Introduction Peripheral quantitative computed tomography (pQCT) provides measurements of bone mineral content (BMC), density (BMD) and bone geometry. There is a lack of reference data available for the interpretation of pQCT measurements in children and young adults. The aim of this study was to provide reference data at the distal and midshaft radius. Methods pQCT was used to measure the 4% and 50% sites of the non-dominant radius in a cohort of healthy white Caucasian children and young adults aged between 5 and 25 years. The lambda, mu, sigma (LMS) technique was used to produce gender-specific reference centile curves and LMS tables for calculating individual standard deviations scores. Results The study population consisted of 629 participants (380 males). Reference centile curves were produced; total and trabecular BMD for age (distal radius) and for age and height, bone area (distal and mid-shaft radius), cortical area, cortical thickness, BMC, axial moment of inertia, stress– strain index and muscle area (mid-shaft radius). Conclusions We present gender-specific databases for the assessment of the distal and mid-shaft radius by pQCT. These data can be used as control data for research studies and allow the clinical interpretation of pQCT measurements in children and young adults by age and height.en_US
dc.description.sponsorshipCentral Manchester and Manchester Children’s University Hospital NHS Research Endowment Fund and the support of the National Osteoporosis Society (Camerton, Bath, UK), which awarded Rebecca Ashby a Linda Edwards Memorial Studentship in 2003 and funded the initial part of the study (1997–1998).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1007/s00198-008-0800-2en_US
dc.subjectAdolescent; Bone density; Bone development; Child; Reference values; Tomography; X-ray computeden_US
dc.titleA reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 yearsen_US
dc.status.refereedYesen_US
dc.date.Accepted2008-11-04
dc.date.application2008-12-06
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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