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    Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations

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    Publication date
    2017-06-29
    Author
    Webster, L.
    Groskreutz, D.
    Grinbergs-Saull, A.
    Howard, R.
    O'Brien, J.T.
    Mountain, Gail
    Banerjee, S.
    Woods, B.
    Perneczky, R.
    Lafortune, L.
    Roberts, C.
    McCleery, J.
    Pickett, J.
    Bunn, F.
    Challis, D.
    Charlesworth, G.
    Featherstone, K.
    Fox, C.
    Goodman, C.
    Jones, R.
    Lamb, S.
    Moniz-Cook, E.
    Schneider, J.
    Shepperd, S.
    Surr, Claire A.
    Thompson-Coon, J.
    Ballard, C.
    Brayne, C.
    Burns, A.
    Clare, L.
    Garrard, P.
    Kehoe, P.
    Passmore, P.
    Holmes, C.
    Maidment, I.
    Robinson, L.
    Livingston, G.
    Show allShow less
    Keyword
    Dementia
    Rights
    © 2017 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    There are no disease-modifying treatments for dementia. There is also no consensus on disease modifying outcomes. We aimed to produce the first evidence-based consensus on core outcome measures for trials of disease modification in mild-to-moderate dementia. We defined disease-modification interventions as those aiming to change the underlying pathology. We systematically searched electronic databases and previous systematic reviews for published and ongoing trials of disease-modifying treatments in mild-to-moderate dementia. We included 149/22,918 of the references found; with 81 outcome measures from 125 trials. Trials involved participants with Alzheimer's disease (AD) alone (n = 111), or AD and mild cognitive impairment (n = 8) and three vascular dementia. We divided outcomes by the domain measured (cognition, activities of daily living, biological markers, neuropsychiatric symptoms, quality of life, global). We calculated the number of trials and of participants using each outcome. We detailed psychometric properties of each outcome. We sought the views of people living with dementia and family carers in three cities through Alzheimer's society focus groups. Attendees at a consensus conference (experts in dementia research, disease-modification and harmonisation measures) decided on the core set of outcomes using these results. Recommended core outcomes were cognition as the fundamental deficit in dementia and to indicate disease modification, serial structural MRIs. Cognition should be measured by Mini Mental State Examination or Alzheimer's Disease Assessment Scale-Cognitive Subscale. MRIs would be optional for patients. We also made recommendations for measuring important, but non-core domains which may not change despite disease modification. Most trials were about AD. Specific instruments may be superseded. We searched one database for psychometric properties. This is the first review to identify the 81 outcome measures the research community uses for disease-modifying trials in mild-to-moderate dementia. Our recommendations will facilitate designing, comparing and meta-analysing disease modification trials in mild-to-moderate dementia, increasing their value.
    URI
    http://hdl.handle.net/10454/14462
    Version
    Published version
    Citation
    Webster L, Groskreutz D, Grinbergs-Saull A et al (2017) Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations. PLoS One. 12(6): e0179521.
    Link to publisher’s version
    https://doi.org/10.1371/journal.pone.0179521
    Type
    Article
    Collections
    Health Studies Publications

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