Show simple item record

dc.contributor.authorPaluch, Krzysztof J.
dc.contributor.authorTajber, L.
dc.contributor.authorAdamczyk, B.
dc.contributor.authorCorrigan, O.I.
dc.contributor.authorHealy, A.M.
dc.date.accessioned2018-01-04T14:21:53Z
dc.date.available2018-01-04T14:21:53Z
dc.date.issued2012-10-15
dc.identifier.citationPaluch KJ, Tajber L, Adamczyk B et al (2012) A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability. International Journal of Pharmaceutics. 436(1-2): 873-876.en_US
dc.identifier.urihttp://hdl.handle.net/10454/14362
dc.descriptionYesen_US
dc.description.abstractHigh-dose API powders which are to be tableted by direct compression should have high compactibility and compressibility. This note reports on a novel approach to the manufacture of crystalline powders intended for direct compaction with improved compactibility and compressibility properties. The poorly compactable API, chlorothiazide, was spray dried from a water/acetone solvent mix producing additive-free nanocrystalline microparticles (NCMPs) of median particle size 3.5 μm. Tablets compacted from NCMPs had tensile strengths ranging from 0.5 to 4.6 MPa (compared to 0.6–0.9 MPa for tablets of micronised CTZ) at compression forces ranging from 6 kN to 13 kN. NCMP tablets also had high porosities (34–20%) and large specific surface areas (4.4–4.8 m2/g). The time taken for tablets made of NCMPs to erode was not statistically longer (p > 0.05) than for tablets made of micronised CTZ. Fragmentation of NCMPs on compression was observed. The volume fraction of particles below 1 μm present in the suspension recovered after erosion of NCMP tablets was 34.8 ± 3.43%, while no nanosized particles were detected in the slurry after erosion of compacted micronised CTZ.en_US
dc.description.sponsorshipSolid State Pharmaceutical Cluster (SSPC), supported by Science Foundation Ireland under grant number 07/SRC/B1158.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1016/j.ijpharm.2012.05.074en_US
dc.rights© 2012 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en_US
dc.subjectSpray drying; Tabletability; Specific surface area; Nanocrystalline microparticles; Erosion; Nanosuspensionen_US
dc.titleA novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletabilityen_US
dc.status.refereedYesen_US
dc.date.Accepted2012-05-30
dc.date.application2012-06-15
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-28T01:57:38Z


Item file(s)

Thumbnail
Name:
Paluch_International_Journal_o ...
Size:
2.543Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record