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    A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability

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    Paluch_International_Journal_of_Pharmaceutics.pdf (2.543Mb)
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    Publication date
    2012-10-15
    Author
    Paluch, Krzysztof J.
    Tajber, L.
    Adamczyk, B.
    Corrigan, O.I.
    Healy, A.M.
    Keyword
    Spray drying; Tabletability; Specific surface area; Nanocrystalline microparticles; Erosion; Nanosuspension
    Rights
    © 2012 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    High-dose API powders which are to be tableted by direct compression should have high compactibility and compressibility. This note reports on a novel approach to the manufacture of crystalline powders intended for direct compaction with improved compactibility and compressibility properties. The poorly compactable API, chlorothiazide, was spray dried from a water/acetone solvent mix producing additive-free nanocrystalline microparticles (NCMPs) of median particle size 3.5 μm. Tablets compacted from NCMPs had tensile strengths ranging from 0.5 to 4.6 MPa (compared to 0.6–0.9 MPa for tablets of micronised CTZ) at compression forces ranging from 6 kN to 13 kN. NCMP tablets also had high porosities (34–20%) and large specific surface areas (4.4–4.8 m2/g). The time taken for tablets made of NCMPs to erode was not statistically longer (p > 0.05) than for tablets made of micronised CTZ. Fragmentation of NCMPs on compression was observed. The volume fraction of particles below 1 μm present in the suspension recovered after erosion of NCMP tablets was 34.8 ± 3.43%, while no nanosized particles were detected in the slurry after erosion of compacted micronised CTZ.
    URI
    http://hdl.handle.net/10454/14362
    Version
    Accepted Manuscript
    Citation
    Paluch KJ, Tajber L, Adamczyk B et al (2012) A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability. International Journal of Pharmaceutics. 436(1-2): 873-876.
    Link to publisher’s version
    https://doi.org/10.1016/j.ijpharm.2012.05.074
    Type
    Article
    Collections
    Life Sciences Publications

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