A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability
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2012-10-15Rights
© 2012 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.Peer-Reviewed
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High-dose API powders which are to be tableted by direct compression should have high compactibility and compressibility. This note reports on a novel approach to the manufacture of crystalline powders intended for direct compaction with improved compactibility and compressibility properties. The poorly compactable API, chlorothiazide, was spray dried from a water/acetone solvent mix producing additive-free nanocrystalline microparticles (NCMPs) of median particle size 3.5 μm. Tablets compacted from NCMPs had tensile strengths ranging from 0.5 to 4.6 MPa (compared to 0.6–0.9 MPa for tablets of micronised CTZ) at compression forces ranging from 6 kN to 13 kN. NCMP tablets also had high porosities (34–20%) and large specific surface areas (4.4–4.8 m2/g). The time taken for tablets made of NCMPs to erode was not statistically longer (p > 0.05) than for tablets made of micronised CTZ. Fragmentation of NCMPs on compression was observed. The volume fraction of particles below 1 μm present in the suspension recovered after erosion of NCMP tablets was 34.8 ± 3.43%, while no nanosized particles were detected in the slurry after erosion of compacted micronised CTZ.Version
Accepted ManuscriptCitation
Paluch KJ, Tajber L, Adamczyk B et al (2012) A novel approach to crystallisation of nanodispersible microparticles by spray drying for improved tabletability. International Journal of Pharmaceutics. 436(1-2): 873-876.Link to Version of Record
https://doi.org/10.1016/j.ijpharm.2012.05.074Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1016/j.ijpharm.2012.05.074