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dc.contributor.authorPaluch, Krzysztof J.*
dc.contributor.authorTajber, L.*
dc.contributor.authorCorrigan, O.I.*
dc.contributor.authorHealy, A.M.*
dc.date.accessioned2018-01-04T12:12:47Z
dc.date.available2018-01-04T12:12:47Z
dc.date.issued2012-11
dc.identifier.citationPaluch KJ, Tajber L, Corrigan OI et al (2012) Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system. Journal of Pharmacy and Pharmacology. 64(11): 1570-1582.en_US
dc.identifier.urihttp://hdl.handle.net/10454/14360
dc.descriptionYesen_US
dc.description.abstractObjectives This work investigated the impact of spray drying variables such as feedconcentration, solvent composition and the drying mode, on the micromeriticproperties of chlorothiazide sodium (CTZNa) and chlorothiazide potassium(CTZK).Methods Microparticles were prepared by spray drying and characterised usingthermal analysis, helium pycnometry, laser diffraction, specific surface area analysisand scanning electron microscopy.Key findings Microparticles produced under different process conditions pre-sented several types of morphology.To systematise the description of morphology ofmicroparticles, a novel morphology classification system was introduced. The shapeof the microparticles was described as spherical (1) or irregular (2) and the surfacewas classified as smooth (A) or crumpled (B). Three classes of morphology of micro-particles were discerned visually: class I, non-porous; classes II and III, comprisingdiffering types of porosity characteristics. The interior was categorised as solid/continuous (a), hollow (b), unknown (g) and hollow with microparticulate content(d). Nanoporous microparticles of CTZNa and CTZK, produced without recircula-tion of the drying gas, had the largest specific surface area of 72.3 and 90.2 m2/g,respectively, and presented morphology of class 1BIIIa.Conclusions Alteration of spray drying process variables, particularly solvent com-position and feed concentration can have a significant effect on the morphology ofspray dried microparticulate products. Morphology of spray dried particles may beusefully described using the morphology classification system.en_US
dc.description.sponsorshipThe Irish Research Council for Science and Engineering Technology (IRCSET), the Solid State Pharmaceutical Cluster (SSPC), supported by Science Foundation Ireland under grant number [07/SRC/B1158] and the Irish Drug Delivery Research Network, a Strategic Research Cluster grant (07/SRC/B1154) under the National Development Plan co-funded by EU Structural Funds and Science Foundation Ireland.en_US
dc.language.isoenen_US
dc.rights© 2012 Wiley This is the peer reviewed version of the following article: Paluch KJ, Tajber L, Corrigan OI et al (2012) Impact of process variables on the micromeritic and physicochemical properties of spraydried porous microparticles, part I: introduction of a new morphology classification system. Journal of Pharmacy and Pharmacology. 64(11): 1570-1582. , which has been published in final form at http://dx.doi.org/10.1111/j.2042-7158.2012.01539.x. This article may be used for noncommercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectSpray drying; Morphology; Solvent; Specific surface area; Amorphous; Nanoporous microparticlesen_US
dc.titleImpact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification systemen_US
dc.status.refereedYesen_US
dc.date.Accepted2012-04-17
dc.date.application2012-06-04
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
dc.identifier.doihttps://doi.org/10.1111/j.2042-7158.2012.01539.x
refterms.dateFOA2018-07-28T01:57:30Z


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