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    Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate

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    Publication date
    2004
    Author
    Kirwan, Ian G.
    Loadman, Paul M.
    Swaine, David J.
    Anthoney, Alan
    Pettit, G.R.
    Lippert III, J.W.
    Shnyder, Steven D.
    Cooper, Patricia A.
    Bibby, Michael C.
    Keyword
    Combretastatin; Prodrugs; Preclinical; Pharmacokinetic; Tumors; Preclinical studies; Metabolism
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Purpose: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical trials, but recent preclinical studies have shown that CA1P displays a greater antitumor effect than the combretastatin A4 (CA4) analog at equal doses. The aim of this study, therefore, is to compare pharmacokinetics and metabolism of the two compounds to determine whether pharmacokinetics plays a role in their differential activity. Experimental Design: NMRI mice bearing MAC29 tumors received injection with either CA4P or CA1P at a therapeutic dose of 150 mg/kg-1 , and profiles of both compounds and their metabolites analyzed by a sensitive and specific liquid chromatography/mass spectroscopy method. Results: The metabolic profile of both compounds is complex, with up to 14 metabolites being detected for combretastatin A1 (CA1) in the plasma. Many of these metabolites have been identified by liquid chromatography/mass spectroscopy. Initial studies, however, focused on the active components CA4 and CA1, where plasma and tumor areas under the curve were 18.4 and 60.1 microgram/h/ml-1 for CA4, and 10.4 and 13.1 microgram/h/ml-1 for CA1, respectively. In vitro metabolic comparisons of the two compounds strongly suggest that CA1 is metabolized to a more reactive species than the CA4. Conclusions: Although in vitro studies suggest that variable rates of tumor-specific prodrug dephosphorylation may explain these differences in pharmacokinetics profiles, the improved antitumor activity and altered pharmacokinetic profile of CA1 may be due to the formation of a more reactive metabolite.
    URI
    http://hdl.handle.net/10454/13684
    Version
    No full-text in the repository
    Citation
    Kirwan IG, Loadman PM, Swaine DJ, Anthoney A, Pettit GR, Lippert III JW, Shnyder SD, Cooper PA and Bibby MC (2004) Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate. Clinical Cancer Research.10 (4): 1446-1453.
    Link to publisher’s version
    http://clincancerres.aacrjournals.org/cgi/reprint/10/4/1446
    Type
    Article
    Collections
    Life Sciences Publications

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