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dc.contributor.authorKulkarni, Chaitrali S.*
dc.contributor.authorKelly, Adrian L.*
dc.contributor.authorGough, Timothy D.*
dc.contributor.authorJadhav, V.*
dc.contributor.authorSingh, K.*
dc.contributor.authorParadkar, Anant R*
dc.date.accessioned2017-10-25T11:41:10Z
dc.date.available2017-10-25T11:41:10Z
dc.date.issued2017-11
dc.identifier.citationKulkarni C, Kelly AL, Gough T et al (2017) Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug. Drug Development and Industrial Pharmacy. 44(2): 206-214.
dc.identifier.urihttp://hdl.handle.net/10454/13552
dc.descriptionYes
dc.description.abstractHot melt extrusion has been used to produce a solid dispersion of the thermolabile drug artemisinin. Formulation and process conditions were optimised prior to evaluation of dissolution and biopharmaceutical performance. Soluplus®, a low Tg amphiphilic polymer especially designed for solid dispersions enabled melt extrusion at 110ºC although some drug-polymer incompatibility was observed. Addition of 5% citric acid as a pH modifier was found to suppress the degradation. The area under plasma concentration time curve (AUC0-24hr) and peak plasma concentration (Cmax) were four times higher for the modified solid dispersion compared to that of pure artemisinin.
dc.description.sponsorshipEPSRC grant no (EP/J003360/1) and UKIERI: UK-India Education and Research Initiative (TPR 26).
dc.language.isoen
dc.rights© 2017 Informa UK Limited, trading as Taylor & Francis Group. This is an Author's Original Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 16-11-2017 available online at http://www.tandfonline.com/10.1080/03639045.2017.1386200
dc.subjectThermolabile drug
dc.subjectArtemisinin
dc.subjectSoluplus®
dc.subjectCompatibility
dc.subjectBioavailability
dc.subjectExtrusion
dc.titleApplication of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug
dc.status.refereedYes
dc.date.Accepted2017-09-08
dc.date.application2017-11-16
dc.typeArticle
dc.type.versionAccepted manuscript
dc.identifier.doihttps://doi.org/10.1080/03639045.2017.1386200
dc.rights.licenseUnspecified
dc.openaccess.statusopenAccess


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