BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    View/Open
    Paradkar_et_al_Drug_Development_&_Industrial_Pharmacy.pdf (625.9Kb)
    Download
    Publication date
    2017-11
    Author
    Kulkarni, Chaitrali S.
    Kelly, Adrian L.
    Gough, Timothy D.
    Jadhav, V.
    Singh, K.
    Paradkar, Anant R.
    Keyword
    Extrusion; Thermolabile drug; Artemisinin; Soluplus®; Compatibility; Bioavailability
    Rights
    © 2017 Informa UK Limited, trading as Taylor & Francis Group. This is an Author's Original Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 16-11-2017 available online at http://www.tandfonline.com/10.1080/03639045.2017.1386200
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Hot melt extrusion has been used to produce a solid dispersion of the thermolabile drug artemisinin. Formulation and process conditions were optimised prior to evaluation of dissolution and biopharmaceutical performance. Soluplus®, a low Tg amphiphilic polymer especially designed for solid dispersions enabled melt extrusion at 110ºC although some drug-polymer incompatibility was observed. Addition of 5% citric acid as a pH modifier was found to suppress the degradation. The area under plasma concentration time curve (AUC0-24hr) and peak plasma concentration (Cmax) were four times higher for the modified solid dispersion compared to that of pure artemisinin.
    URI
    http://hdl.handle.net/10454/13552
    Version
    Accepted Manuscript
    Citation
    Kulkarni C, Kelly AL, Gough T et al (2017) Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug. Drug Development and Industrial Pharmacy. 44(2): 206-214.
    Link to publisher’s version
    https://doi.org/10.1080/03639045.2017.1386200
    Type
    Article
    Collections
    Life Sciences Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.