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dc.contributor.authorInam, M.*
dc.contributor.authorCambridge, G.*
dc.contributor.authorPitto-Barry, Anaïs*
dc.contributor.authorLaker, Z.P.L.*
dc.contributor.authorWilson, N.R.*
dc.contributor.authorMathers, R.T.*
dc.contributor.authorDove, A.P.*
dc.contributor.authorO'Reilly, R.K.*
dc.date.accessioned2017-10-24T15:27:12Z
dc.date.available2017-10-24T15:27:12Z
dc.date.issued2017-04-13
dc.identifier.citationInam M, Cambridge G, Pitto-Barry A, Laker ZPL, Wilson NR, Mathers RT, Dove AP and O'Reilly RK (2017) 1D vs. 2D shape selectivity in the crystallization-driven self-assembly of polylactide block copolymers. Chemical Science. 8(6): 4223-4230.en_US
dc.identifier.urihttp://hdl.handle.net/10454/13527
dc.descriptionyesen_US
dc.description.abstract2D materials such as graphene, LAPONITE® clays or molybdenum disulfide nanosheets are of extremely high interest to the materials community as a result of their high surface area and controllable surface properties. While several methods to access 2D inorganic materials are known, the investigation of 2D organic nanomaterials is less well developed on account of the lack of ready synthetic accessibility. Crystallization-driven self-assembly (CDSA) has become a powerful method to access a wide range of complex but precisely-defined nanostructures. The preparation of 2D structures, however, particularly those aimed towards biomedical applications, is limited, with few offering biocompatible and biodegradable characteristics as well as control over self-assembly in two dimensions. Herein, in contrast to conventional self-assembly rules, we show that the solubility of polylactide (PLLA)-based amphiphiles in alcohols results in unprecedented shape selectivity based on unimer solubility. We use log Poct analysis to drive solvent selection for the formation of large uniform 2D diamond-shaped platelets, up to several microns in size, using long, soluble coronal blocks. By contrast, less soluble PLLA-containing block copolymers yield cylindrical micelles and mixed morphologies. The methods developed in this work provide a simple and consistently reproducible protocol for the preparation of well-defined 2D organic nanomaterials, whose size and morphology are expected to facilitate potential applications in drug delivery, tissue engineering and in nanocomposites.en_US
dc.description.sponsorshipUniversity of Warwick, Materials GRP, EPSRC, The Royal Society, ERCen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1039/c7sc00641aen_US
dc.rights© 2017 Royal Society of Chemistry. Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en_US
dc.subjectBlock copolymers; Crystallisation-driven self-assembly; Polylactide; 2D materialsen_US
dc.title1D vs. 2D shape selectivity in the crystallization-driven self-assembly of polylactide block copolymersen_US
dc.status.refereedYesen_US
dc.date.application2017-04-13
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-25T13:36:50Z


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