BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    •   Bradford Scholars
    • Life Sciences
    • Life Sciences Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Mitochondrial Biogenesis: Pharmacological Approaches

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    View/Open
    Main article (198.0Kb)
    Download
    Publication date
    2014
    Author
    Valero-Grinan, Teresa M.
    Keyword
    Mitochondrial biogenesis
    Pharmacological approaches
    Treatment potential
    Diseases of mitochondrial origin
    Rights
    © 2014 Bentham Science. Reproduced in accordance with the publisher's self-archiving policy. The published manuscript is available at EurekaSelect via https://doi.org/10.2174/138161282035140911142118.
    Peer-Reviewed
    No
    Open Access status
    openAccess
    
    Metadata
    Show full item record
    Abstract
    Organelle biogenesis is concomitant to organelle inheritance during cell division. It is necessary that organelles double their size and divide to give rise to two identical daughter cells. Mitochondrial biogenesis occurs by growth and division of pre-existing organelles and is temporally coordinated with cell cycle events [1]. However, mitochondrial biogenesis is not only produced in association with cell division. It can be produced in response to an oxidative stimulus, to an increase in the energy requirements of the cells, to exercise training, to electrical stimulation, to hormones, during development, in certain mitochondrial diseases, etc. [2]. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. Recent discoveries have raised attention to mitochondrial biogenesis as a potential target to treat diseases which up to date do not have an efficient cure. Mitochondria, as the major ROS producer and the major antioxidant producer exert a crucial role within the cell mediating processes such as apoptosis, detoxification, Ca2+ buffering, etc. This pivotal role makes mitochondria a potential target to treat a great variety of diseases. Mitochondrial biogenesis can be pharmacologically manipulated. This issue tries to cover a number of approaches to treat several diseases through triggering mitochondrial biogenesis. It contains recent discoveries in this novel field, focusing on advanced mitochondrial therapies to chronic and degenerative diseases, mitochondrial diseases, lifespan extension, mitohormesis, intracellular signaling, new pharmacological targets and natural therapies. It contributes to the field by covering and gathering the scarcely reported pharmacological approaches in the novel and promising field of mitochondrial biogenesis.
    URI
    http://hdl.handle.net/10454/13341
    Version
    Accepted manuscript
    Citation
    Valero-Grinan T (2014) Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches). Current Pharmaceutical Design. 20(35): 5507-5509.
    Link to Version of Record
    https://doi.org/10.2174/138161282035140911142118
    Type
    Editorial
    ae974a485f413a2113503eed53cd6c53
    https://doi.org/10.2174/138161282035140911142118
    Scopus Count
    Collections
    Life Sciences Publications

    entitlement

     

    Show Statistical Information

    DSpace software (copyright © 2002 - 2024)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.