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    The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis

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    Publication date
    2017
    Author
    Wall, M.J.
    Corrêa, Sonia A.L.
    Keyword
    AMPA receptors; Arc/Arg3.1; Adaptor protein 2; Endocytosis; Rectification
    Rights
    (c) 2017 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    The activity-regulated cytoskeleton associated protein (Arc/Arg3.1) plays a key role in determining synaptic strength through facilitation of AMPA receptor (AMPAR) endocytosis. Although there is considerable data on the mechanism by which Arc induction controls synaptic plasticity and learning behaviours, several key mechanistic questions remain. Here we review data on the link between Arc expression and the clathrin-mediated endocytic pathway which internalises AMPARs and discuss the significance of Arc binding to the clathrin adaptor protein 2 (AP-2) and to endophilin/dynamin. We consider which AMPAR subunits are selected for Arc-mediated internalisation, implications for synaptic function and consider Arc as a therapeutic target.
    URI
    http://hdl.handle.net/10454/13240
    Version
    Accepted Manuscript
    Citation
    Wall MJ and Correa SAL (2017) The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. Accepted for publication
    Link to publisher’s version
    https://doi.org/10.1016/j.semcdb.2017.09.005
    Type
    Article
    Collections
    Life Sciences Publications

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