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    Diverse mechanisms underlying the regulation of ion channels by carbon monoxide

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    Publication date
    2015-03
    Author
    Peers, C.
    Boyle, J.P.
    Scragg, J.L.
    Dallas, M.L.
    Al-Owais, M.M.
    Hettiarachichi, N.T.
    Elies, Jacobo
    Johnson, E.
    Gamper, N.
    Steele, D.S.
    Keyword
    Carbon monoxide; Ion channels; CO signalling; T-type Ca2+ channels
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Carbon monoxide (CO) is firmly established as an important, physiological signalling molecule as well as a potent toxin. Through its ability to bind metal-containing proteins, it is known to interfere with a number of intracellular signalling pathways, and such actions can account for its physiological and pathological effects. In particular, CO can modulate the intracellular production of reactive oxygen species, NO and cGMP levels, as well as regulate MAPK signalling. In this review, we consider ion channels as more recently discovered effectors of CO signalling. CO is now known to regulate a growing number of different ion channel types, and detailed studies of the underlying mechanisms of action are revealing unexpected findings. For example, there are clear areas of contention surrounding its ability to increase the activity of high conductance, Ca2+-sensitive K+ channels. More recent studies have revealed the ability of CO to inhibit T-type Ca2+ channels and have unveiled a novel signalling pathway underlying tonic regulation of this channel. It is clear that the investigation of ion channels as effectors of CO signalling is in its infancy, and much more work is required to fully understand both the physiological and the toxic actions of this gas. Only then can its emerging use as a therapeutic tool be fully and safely exploited.
    URI
    http://hdl.handle.net/10454/12204
    Version
    No full-text in the repository
    Citation
    Peers C, Boyle JP, Scragg JL et al (2015) Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. British Journal of Pharmacology. 172(6): 1546-1556.
    Link to publisher’s version
    https://doi.org/10.1111/bph.12760
    Type
    Article
    Collections
    Life Sciences Publications

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