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dc.contributor.authorNithianandarajah-Jones, G.N.*
dc.contributor.authorWilm, B.*
dc.contributor.authorGoldring, C.E.*
dc.contributor.authorMuller, Jurgen*
dc.contributor.authorCross, M.J.*
dc.date.accessioned2017-06-08T08:52:49Z
dc.date.available2017-06-08T08:52:49Z
dc.date.issued2014-12-01
dc.identifier.citationNithianandarajah-Jones GN, Wilm B, Goldring CE et al (2014) The role of ERK5 in endothelial cell function. Biochemical Society Transactions. 42(6): 1584-1589.en_US
dc.identifier.urihttp://hdl.handle.net/10454/12161
dc.descriptionYesen_US
dc.description.abstractExtracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.en_US
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council, the Medical Research Council and the Wellcome Trusten_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1042/BST20140276en_US
dc.rights© 2014 The Authors. Full-text reproduced with author permission, and in accordance with the publisher’s self-archiving policy.en_US
dc.subjectERK5; MAPK1; BMK1; MAPK; Cardiovascular development; Endothelial cell functionen_US
dc.titleThe role of ERK5 in endothelial cell functionen_US
dc.status.refereedYesen_US
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-27T01:26:32Z


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