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dc.contributor.authorAhmedah, H.T.*
dc.contributor.authorPatterson, Laurence H.*
dc.contributor.authorShnyder, Steven D.*
dc.contributor.authorSheldrake, Helen M.*
dc.date.accessioned2017-06-06T13:51:20Z
dc.date.available2017-06-06T13:51:20Z
dc.date.issued2017-05-26
dc.identifier.citationAhmedah HT, Patterson LH, Shnyder SD et al (2017) RGD-Binding Integrins in Head and Neck Cancers. Cancers. 9(6). 56.en_US
dc.identifier.urihttp://hdl.handle.net/10454/12124
dc.descriptionYesen_US
dc.description.abstractAlterations in integrin expression and function promote tumour growth, invasion, metastasis and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency to metastasise. They express a wide range of integrin receptors. Expression of the αv and β1 subunits has been explored relatively extensively and linked to tumour progression and metastasis. Individual receptors αvβ3 and αvβ5 have proved popular targets for diagnostic and therapeutic agents but lesser studied receptors, such as αvβ6, αvβ8, and β1 subfamily members, also show promise. This review presents the current knowledge of integrin expression and function in squamous cell carcinoma of the head and neck (HNSCC), with a particular focus on the RGD-binding integrins, in order to highlight the potential of integrins as targets for personalised tumour specific identification and therapy.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.3390/cancers9060056en_US
dc.rights© 2017 The Authors. This is an open access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectIntegrin αv; β1; β3; β6; Arginine-glycine-aspartate (RGD); Metastasis; Treatment resistanceen_US
dc.titleRGD-Binding Integrins in Head and Neck Cancersen_US
dc.status.refereedYesen_US
dc.date.Accepted2017-05-23
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-27T01:26:08Z


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