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dc.contributor.authorDenniss, Jonathan*
dc.contributor.authorBaggaley, H.C.*
dc.contributor.authorBrown, G.M.*
dc.contributor.authorRubin, G.S.*
dc.contributor.authorAstle, A.T.*
dc.date.accessioned2017-06-02T16:21:04Z
dc.date.available2017-06-02T16:21:04Z
dc.date.issued2017-05
dc.identifier.citationDenniss J, Baggaley HC, Brown G et al (2017) Properties of visual field defects around the monocular preferred retinal locus in age-related macular degeneration. Investigative Ophthalmology and Visual Science. 58(5): 2652-2658.en_US
dc.identifier.urihttp://hdl.handle.net/10454/12116
dc.descriptionYesen_US
dc.description.abstractPURPOSE. To compare microperimetric sensitivity around the monocular preferred retinal locus (mPRL) in age-related macular degeneration (AMD) to normative data, and to describe the characteristics of visual field defects around the mPRL in AMD. METHODS. Participants with AMD (total n ¼ 185) were either prospectively recruited (n ¼ 135) or retrospectively reviewed from an existing database (n ¼ 50). Participants underwent microperimetry using a test pattern (37 point, 58 radius) centered on their mPRL. Sensitivities were compared to normative data by spatial interpolation, and conventional perimetric indices were calculated. The location of the mPRL relative to the fovea and to visual field defects was also investigated. RESULTS. Location of mPRL varied approximately 158 horizontally and vertically. Visual field loss within 58 of the mPRL was considerable in the majority of participants (median mean deviation 14.7 dB, interquartile range [IQR] 19.6 to 9.6 dB, median pattern standard deviation 7.1 dB [IQR 4.8–9.0 dB]). Over 95% of participants had mean total deviation worse than 2 dB across all tested locations and similarly within 18 of their mPRL. A common pattern of placing the mPRL just foveal to a region of normal pattern deviation was found in 78% of participants. Total deviation was outside normal limits in this region in 68%. CONCLUSIONS. Despite altering fixation to improve vision, people with AMD exhibit considerable visual field loss at and around their mPRL. The location of the mPRL was typically just foveal to, but not within, a region of relatively normal sensitivity for the individual, suggesting that a combination of factors drives mPRL selection.en_US
dc.description.sponsorshipThis report presents independent research funded by the NIHRen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1167/iovs.16-21086en_US
dc.rightsCopyright 2017 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.subjectAge-related macular degeneration; Perimetry; Fixation; Microperimetry; Scotomaen_US
dc.titleProperties of visual field defects around the monocular preferred retinal locus in age-related macular degenerationen_US
dc.status.refereedYesen_US
dc.date.Accepted2017-03-27
dc.date.application2017-05
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-25T13:34:10Z


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