Show simple item record

dc.contributor.authorPagire, Sudhir K.*
dc.contributor.authorJadav, Niten B.*
dc.contributor.authorVangala, Venu R.*
dc.contributor.authorWhiteside, Benjamin R.*
dc.contributor.authorParadkar, Anant R.*
dc.date.accessioned2017-04-13T13:37:31Z
dc.date.available2017-04-13T13:37:31Z
dc.date.issued2017
dc.identifier.citationPagire SK, Jadav N, Vangala VR et al (2017) Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs. Journal of Pharmaceutical Sciences. 106(8): 2009-2014.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11805
dc.descriptionYesen_US
dc.description.abstractPolymorphism in active pharmaceutical ingredients (APIs) can be regarded as critical for the potential that crystal form can have on the quality, efficacy and safety of the final drug product. The current contribution aims to characterize thermodynamic interrelationship of a dimorphic co-crystal, FI and FII, involving carbamazepine (CBZ) and saccharin (SAC) molecules. Supramolecular synthesis of CBZ-SAC FI and FII have been performed using thermo-kinetic methods and systematically characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), solubility and slurry measurements. According to Berger and Ramberger’s heat of fusion rule, FI (ΔHfus = 121.1 J/g, mp 172.5 °C) and FII (ΔHfus= 110.3 J/g, mp 164.7 °C) are monotropically related. The solubility and van’t Hoff plot results suggest that FI stable and FII metastable forms. This study reveals that CBZ-SAC co-crystal phases, FI or FII, could be stable to heat induced stresses, however, FII converts to FI during solution mediated transformation.en_US
dc.description.sponsorshipAuthors would like to acknowledge UKIERI (TPR 26), EPSRC (EP/J003360/1, EP/L027011/1) for the support. Open Access funded by Engineering and Physical Sciences Research Councilen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://doi.org/10.1016/j.xphs.2017.04.017
dc.rights© 2017 The Authors. Published by Elsevier Inc. on behalf of the American Pharmacists Association. This is an open access article available under the terms of the Creative Commons Attribution License (CC BY 4.0).en_US
dc.subjectPolymorphism; Cocrystal polymorphs; Thermodynamic interrelationship; Monotropic systemen_US
dc.titleThermodynamic investigation of carbamazepine-saccharin co-crystal polymorphsen_US
dc.status.refereedYesen_US
dc.date.Accepted2017-04-10
dc.date.application2017-04-21
dc.typeArticleen_US
dc.type.versionPublished Versionen_US
refterms.dateFOA2018-07-25T16:09:07Z


Item file(s)

Thumbnail
Name:
Paradkar_Jnl_of_Pharmaceutical ...
Size:
833.9Kb
Format:
PDF
Description:
To keep suppressed
Thumbnail
Name:
Paradkar_Journal_of_Pharmaceut ...
Size:
920.8Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record