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dc.contributor.authorLaganà, M.M.*
dc.contributor.authorShepherd, Simon J.*
dc.contributor.authorCecconi, P.*
dc.contributor.authorBeggs, Clive B.*
dc.date.accessioned2017-04-13T11:46:57Z
dc.date.available2017-04-13T11:46:57Z
dc.date.issued2017-07
dc.identifier.citationLaganà MM, Shepherd SJ, Cecconi P and Beggs CB (2017) Intracranial volumetric changes govern cerebrospinal fluid flow in the Aqueduct of Sylvius in healthy adults. Biomedical Signal Processing and Control. 36: 84–92.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11804
dc.descriptionyesen_US
dc.description.abstractPurpose To characterize the intracranial volumetric changes that influence the cerebrospinal fluid (CSF) pulse in the Aqueduct of Sylvius (AoS). Materials and methods Neck MRI data were acquired from 12 healthy adults (8 female and 4 males; mean age = 30.9 years), using a 1.5 T scanner. The intracranial arterial, venous and CSF volumes changes, together with the aqueductal CSF (aCSF) volume, were estimated from flow rate data acquired at C2/C3 level and in the AoS. The correlations and temporal relationships among these volumes were computed. Results The aCSF volumetric changes were strongly correlated (r = 0.967, p < 0.001) with the changes in intracranial venous volume, whose peak occurred 7.0% of cardiac cycle (p = 0.023) before peak aCSF volume, but less correlated with the intracranial arterial and CSF volume changes (r = −0.664 and 0.676 respectively, p < 0.001). The intracranial CSF volume change was correlated with the intracranial venous volume change (r = 0.820, p < 0.001), whose peak occurred slightly before (4.2% of CC, p = 0.059). Conclusion The aCSF pulse is strongly correlated with intracranial venous volume, with expansion of the cortical veins occurring prior to aCSF flow towards the third ventricle. Both caudal-cranial aCSF flow and venous blood retention occur when arterial blood volume is at a minimum.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.bspc.2017.03.019en_US
dc.rights© 2017 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.subjectAqueduct of Sylvius; Phase contrast MRI; Cerebrospinal fluid; Intracranial volumetric changes; Venous flow; Arterial flow; Intracranial vascular modelen_US
dc.titleIntracranial volumetric changes govern cerebrospinal fluid flow in the Aqueduct of Sylvius in healthy adultsen_US
dc.status.refereedyesen_US
dc.date.Accepted2017-03-29
dc.date.application2017-04-08
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-27T01:22:04Z


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