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dc.contributor.authorBeggs, Clive B.*
dc.contributor.authorMagnano, C.R.*
dc.contributor.authorShepherd, Simon J.*
dc.contributor.authorMarr, K.*
dc.contributor.authorValnarov, V.*
dc.contributor.authorHojnacki, D.*
dc.contributor.authorBergsland, N.*
dc.contributor.authorBelov, P.*
dc.contributor.authorGrisafi, S.*
dc.contributor.authorDwyer, Michael G.*
dc.contributor.authorCarl, Ellen*
dc.contributor.authorWeinstock-Guttman, B.*
dc.contributor.authorZivadinov, R.*
dc.date.accessioned2017-04-12T16:48:40Z
dc.date.available2017-04-12T16:48:40Z
dc.date.issued2014-10
dc.identifier.citationBeggs, C. B., Magnano, C., Shepherd, S. J., Marr, K., Valnarov, V., Hojnacki, D., Bergsland, N., Belov, P., Grisafi, S., Dwyer, M. G., Carl, E., Weinstock-Guttman, B. and Zivadinov, R. (2014) Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. Journal of Magnetic Resonance Imaging. 40: 1215–1222.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11801
dc.descriptionyesen_US
dc.description.abstractTo investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius (AoS) in chronic cerebrospinal venous insufficiency (CCSVI)-positive and -negative healthy individuals using cine phase contrast imaging. Materials and Methods Fifty-one healthy individuals (32 CCSVI-negative and 19 age-matched CCSVI-positive subjects) were examined using Doppler sonography (DS). Diagnosis of CCSVI was established if subjects fulfilled ≥2 venous hemodynamic criteria on DS. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and routine 3T MRI outcomes. Results CCSVI was associated with increased CSF pulsatility in the AoS. Net positive CSF flow was 32% greater in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.008). This was accompanied by a 28% increase in the mean aqueductal characteristic signal (ie, the AoS cross-sectional area over the cardiac cycle) in the CCSVI-positive group compared with the CCSVI-negative group (P = 0.021). Conclusion CSF dynamics are altered in CCSVI-positive healthy individuals, as demonstrated by increased pulsatility. This is accompanied by enlargement of the AoS, suggesting that structural changes may be occurring in the brain parenchyma of CCSVI-positive healthy individualsen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1002/jmri.24468en_US
dc.rights© 2014 Wiley. This is the peer reviewed version of the following article: Beggs, C. B., Magnano, C., Shepherd, S. J., Marr, K., Valnarov, V., Hojnacki, D., Bergsland, N., Belov, P., Grisafi, S., Dwyer, M. G., Carl, E., Weinstock-Guttman, B. and Zivadinov, R. (2014) Aqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflow. Journal of Magnetic Resonance Imaging. 40: 1215–1222, which has been published in final form at http://dx.doi.org/10.1002/jmri.24468. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectCerebrospinal fluid (CSF) dynamic: Chronic cerebrospinal venous insufficiency (CCSVI); Cerebral venous outflow; Aqueduct of Sylvius; Healthy individuals; Lateral ventricle volume; Cine phase contrast imaging.en_US
dc.titleAqueductal cerebrospinal fluid pulsatility in healthy individuals is affected by impaired cerebral venous outflowen_US
dc.status.refereedyesen_US
dc.date.Accepted2013-09-15
dc.date.application2013-11-08
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-27T01:21:45Z


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