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    Erythropoietin drives breast cancer progression by activation of its receptor EPOR

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    El-Tanani_et_al_Oncotarget.pdf (5.575Mb)
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    Publication date
    2017-03-18
    Author
    Chan, K.K.
    Matchett, K.B.
    Coulter, J.A.
    Yuen, H-F.
    McCrudden, C.M.
    Zhang, S-D.
    Irwin, G.W.
    Davidson, M.A.
    Rülicke, T.
    Schober, S.
    Hengst, L.
    Jaekel, H.
    Platt-Higgins, A.
    Rudland, P.S.
    Mills, K.I.
    Maxwell, P.
    El-Tanani, Mohamed
    Lappin, T.R.
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    Keyword
    EPO; EPOR; Breast cancer; MYC; Apoptosis
    Rights
    © 2017 Chan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    Peer-Reviewed
    Yes
    
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    Abstract
    Breast cancer is a leading cause of cancer-related deaths. Anemia is common in breast cancer patients and can be treated with blood transfusions or with recombinant erythropoietin (EPO) to stimulate red blood cell production. Clinical studies have indicated decreased survival in some groups of cancer patients treated with EPO. Numerous tumor cells express the EPO receptor (EPOR), posing a risk that EPO treatment would enhance tumor growth, but the mechanisms involved in breast tumor progression are poorly understood. Here, we have examined the functional role of the EPO-EPOR axis in preclinical models of breast cancer. EPO induced the activation of PI3K/AKT and MAPK pathways in human breast cancer cell lines. EPOR knockdown abrogated human tumor cell growth, induced apoptosis through Bim, reduced invasiveness, and caused downregulation of MYC expression. EPO-induced MYC expression is mediated through the PI3K/AKT and MAPK pathways, and overexpression of MYC partially rescued loss of cell proliferation caused by EPOR downregulation. In a xenotransplantation model, designed to simulate recombinant EPO therapy in breast cancer patients, knockdown of EPOR markedly reduced tumor growth. Thus, our experiments in vitro and in vivo demonstrate that functional EPOR signaling is essential for the tumor-promoting effects of EPO and underline the importance of the EPO-EPOR axis in breast tumor progression.
    URI
    http://hdl.handle.net/10454/11644
    Version
    Published version
    Citation
    Chan KK, Matchett KB, Coulter JA et al (2017) Erythropoietin drives breast cancer progression by activation of its receptor EPOR. Oncotarget. 8(24): 38251-38263.
    Link to publisher’s version
    http://dx.doi.org/10.18632/oncotarget.16368
    Type
    Article
    Collections
    Life Sciences Publications

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