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dc.contributor.authorMcLean, Samantha*
dc.contributor.authorHarte, Michael K.*
dc.contributor.authorNeill, Joanna C.*
dc.contributor.authorYoung, A.M.J.*
dc.date.accessioned2017-03-14T17:09:55Z
dc.date.available2017-03-14T17:09:55Z
dc.date.issued2017
dc.identifier.citationMcLean SL, Harte MK, Neill JC and Young AMJ (2017) Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation. Journal of Psychopharmacology. 31(6): 660-666.
dc.identifier.urihttp://hdl.handle.net/10454/11616
dc.descriptionYes
dc.description.abstractRationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly validated animal model for cognitive deficits in schizophrenia. The aim of our study was to investigate the role of PFC dopamine in scPCP-induced deficits in a cognitive task of relevance to the disorder, novel object recognition (NOR). Methods: Twelve adult female Lister Hooded rats received scPCP (2 mg/kg) or vehicle via the intraperitoneal route twice daily for seven days, followed by seven days washout. In vivo microdialysis was carried out prior to, during and following the NOR task. Results: Vehicle rats successfully discriminated between novel and familiar objects and this was accompanied by a significant increase in dopamine in the PFC during the retention trial (P<0.01). scPCP produced a significant deficit in NOR (P<0.05 vs. control) and no PFC dopamine increase was observed. Conclusions: These data demonstrate an increase in dopamine during the retention trial in vehicle rats that was not observed in scPCP-treated rats accompanied by cognitive disruption in the scPCP group. This novel finding suggests a mechanism by which cognitive deficits are produced in this animal model and support its use for investigating disorders in which PFC dopamine is central to the pathophysiology.
dc.language.isoen
dc.rights© 2017 The Authors. Published by SAGE. Reproduced in accordance with the publisher's self-archiving policy.
dc.subjectDopamine
dc.subjectPrefrontal cortex (PFC)
dc.subjectCognition
dc.subjectPhencyclidine
dc.subjectObject recognition
dc.titleDopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation
dc.status.refereedYes
dc.date.Accepted2017-03-12
dc.date.application2017-04-26
dc.typeArticle
dc.type.versionAccepted manuscript
dc.identifier.doihttps://doi.org/10.1177/0269881117704988
dc.rights.licenseUnspecified
dc.openaccess.statusopenAccess


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