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    Multiple changes in cell wall antigens of isogenic mutants of Streptococcus mutans

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    Publication date
    1993-09
    Author
    Harrington, Dean J.
    Russell, R.R.B.
    Keyword
    Cell wall antigens; Streptococcus mutans; Isogenic mutants
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Isogenic mutants of Streptococcus mutans LT11, deficient in the production of the wall-associated protein antigens A and B, were generated by recombinant DNA technology. The hydrophobicity, adherence, and aggregation of the mutants were compared with those of the parent strain. These studies indicated that hydrophobicity, adherence, and saliva- or sucrose-induced aggregation were unaltered in the A- mutant but that hydrophobicity and adherence to saliva-coated hydroxylapatite were greatly reduced in the B- mutant whilst sucrose-dependent adherence and aggregation were increased. To determine whether these changes correlated with changes in the mutated gene product alone, the levels of a number of cell wall antigens were determined in each of the mutants. The loss of antigen A resulted in significantly reduced levels of wall-associated lipoteichoic acid, and loss of antigen B resulted in reductions in both antigen A and lipoteichoic acid. Data presented here thus suggest that changes in the expression of one wall antigen can have a dramatic effect on the levels of others.
    URI
    http://hdl.handle.net/10454/11596
    Version
    No full-text in the repository
    Citation
    Harrington DJ and Russell RRB (1993) Multiple changes in cell wall antigens of isogenic mutants of Streptococcus mutans. Journal of Bacteriology. 175(18): 5925-5933.
    Link to publisher’s version
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC206673/
    Type
    Article
    Collections
    Life Sciences Publications

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