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dc.contributor.authorHarrington, Dean J.*
dc.contributor.authorGreated, J.S.*
dc.contributor.authorChanter, N.*
dc.contributor.authorSutcliffe, I.C.*
dc.date.accessioned2017-03-10T15:48:55Z
dc.date.available2017-03-10T15:48:55Z
dc.date.issued2000-10
dc.identifier.citationHarrington DJ, Greated SJ, Chanter N et al (2000) Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus. Infection and Immunity. 68(10): 6048-6051.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11589
dc.descriptionNoen_US
dc.description.abstractStreptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the factors that contribute to the virulence of these equine pathogens have not been extensively investigated. Here we demonstrate the presence of a homologue of the Streptococcus pneumoniae PsaA protein in both of these equine pathogens. Inhibition of signal peptide processing by the antibiotic globomycin confirmed the lipoprotein nature of the mature proteins, and surface exposure was confirmed by their release from intact cells by mild trypsinolysis.en_US
dc.description.sponsorshipProject grant 056042 from The Wellcome Trust.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1128/IAI.68.10.6048-6051.2000en_US
dc.subjectLipoproteins; Streptococcus equi; Streptococcus zooepidemicus; Equine pathogensen_US
dc.titleIdentification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicusen_US
dc.status.refereedYesen_US
dc.date.Accepted2000-07-26
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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