Show simple item record

dc.contributor.authorSutcliffe, I.C.*
dc.contributor.authorHarrington, Dean J.*
dc.date.accessioned2017-03-10T12:31:57Z
dc.date.available2017-03-10T12:31:57Z
dc.date.issued2004-11
dc.identifier.citationSutcliffe IC and Harrington DJ (2004) Lipoproteins of Mycobacterium tuberculosis: an abundant and functionally diverse class of cell envelope components. FEMS Microbiology Reviews. 28(5): 645-659.
dc.identifier.urihttp://hdl.handle.net/10454/11581
dc.descriptionNo
dc.description.abstractMycobacterium tuberculosis remains the predominant bacterial scourge of mankind. Understanding of its biology and pathogenicity has been greatly advanced by the determination of whole genome sequences for this organism. Bacterial lipoproteins are a functionally diverse class of membrane-anchored proteins. The signal peptides of these proteins direct their export and post-translational lipid modification. These signal peptides are amenable to bioinformatic analysis, allowing the lipoproteins encoded in whole genomes to be catalogued. This review applies bioinformatic methods to the identification and functional characterisation of the lipoproteins encoded in the M. tuberculosis genomes. Ninety nine putative lipoproteins were identified and so this family of proteins represents ca. 2.5% of the M. tuberculosis predicted proteome. Thus, lipoproteins represent an important class of cell envelope proteins that may contribute to the virulence of this major pathogen.
dc.language.isoen
dc.subjectBioinformatics
dc.subjectGenome
dc.subjectLipoprotein
dc.subjectMycobacterium tuberculosis
dc.subjectPeriplasm
dc.subjectVirulence factor
dc.titleLipoproteins of Mycobacterium tuberculosis: an abundant and functionally diverse class of cell envelope components
dc.status.refereedYes
dc.date.Accepted18/06/2004
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1016/j.femsre.2004.06.002
dc.openaccess.statusclosedAccess


This item appears in the following Collection(s)

Show simple item record