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dc.contributor.authorSutcliffe, I.C.*
dc.contributor.authorHarrington, Dean J.*
dc.date.accessioned2017-03-10T12:31:57Z
dc.date.available2017-03-10T12:31:57Z
dc.date.issued2004-11
dc.identifier.citationSutcliffe IC and Harrington DJ (2004) Lipoproteins of Mycobacterium tuberculosis: an abundant and functionally diverse class of cell envelope components. FEMS Microbiology Reviews. 28(5): 645-659.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11581
dc.descriptionnoen_US
dc.description.abstractMycobacterium tuberculosis remains the predominant bacterial scourge of mankind. Understanding of its biology and pathogenicity has been greatly advanced by the determination of whole genome sequences for this organism. Bacterial lipoproteins are a functionally diverse class of membrane-anchored proteins. The signal peptides of these proteins direct their export and post-translational lipid modification. These signal peptides are amenable to bioinformatic analysis, allowing the lipoproteins encoded in whole genomes to be catalogued. This review applies bioinformatic methods to the identification and functional characterisation of the lipoproteins encoded in the M. tuberculosis genomes. Ninety nine putative lipoproteins were identified and so this family of proteins represents ca. 2.5% of the M. tuberculosis predicted proteome. Thus, lipoproteins represent an important class of cell envelope proteins that may contribute to the virulence of this major pathogen.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.femsre.2004.06.002en_US
dc.subjectBioinformatics; Genome; Lipoprotein; Mycobacterium tuberculosis; Periplasm; Virulence factoren_US
dc.titleLipoproteins of Mycobacterium tuberculosis: an abundant and functionally diverse class of cell envelope componentsen_US
dc.status.refereedYesen_US
dc.date.Accepted2004-06-18
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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