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    Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em

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    Publication date
    2009-01
    Author
    Hutchings, M.I.
    Palmer, T.
    Harrington, Dean J.
    Sutcliffe, I.C.
    Keyword
    Gram-positive bacterial lipoproteins; Peripheral membrane proteins; Whole genome sequence data; Protein export
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials.
    URI
    http://hdl.handle.net/10454/11571
    Version
    No full-text in the repository
    Citation
    Hutchings MI, Palmer T, Harrington DJ et al (2009) Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em. Trends in Microbiology. 17(1): 13-21.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.tim.2008.10.001
    Type
    Article
    Collections
    Life Sciences Publications

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