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dc.contributor.authorYang, Q.*
dc.contributor.authorZhang, M.*
dc.contributor.authorHarrington, Dean J.*
dc.contributor.authorBlack, G.W.*
dc.contributor.authorSutcliffe, I.C.*
dc.date.accessioned2017-03-08T12:21:50Z
dc.date.available2017-03-08T12:21:50Z
dc.date.issued2010-06
dc.identifier.citationYang Q, Zhang M, Harrington DJ et al (2010) A proteomic investigation of Streptococcus agalactiae grown under conditions associated with neonatal exposure reveals the upregulation of the putative virulence factor C protein β antigen. International Journal of Medical Microbiology. 300(5): 331-337.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11569
dc.descriptionNoen_US
dc.description.abstractStreptococcus agalactiae is a major neonatal pathogen that is able to adapt to a variety of host environments, including both rectal and vaginal maternal carriage, growth in amniotic fluid and at various neonatal body sites. As such it is important to elucidate the patterns of protein expression that are associated with S. agalactiae growth under these different in vivo conditions. To this end, we have grown S. agalactiae strain A909 under in vitro conditions reflecting those associated with maternal vaginal carriage (low pH, low oxygen, nutrient stress) and those associated with exposure to body fluids during invasive disease (neutral pH, aeration, nutrient sufficient). The protein profiles of bacterial cells grown under each of these conditions were compared using a proteome approach. A total of 76 proteins were reproducibly identified 16 of which were shown to be differentially expressed. The putative virulence factor C protein β and several proteins linked to resistance to oxidative stress were found to be upregulated under the conditions hypothesised to reflect those associated with foetal exposure to S. agalactiae. Thus, these data add to the currently limited understanding of the molecular basis of S. agalactiae GBS adaptation to different environmental conditions.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.ijmm.2010.01.001en_US
dc.subjectC protein Beta antigen; Colonisation; Group B Streptococcus; Proteomics; Virulence factorsen_US
dc.titleA proteomic investigation of Streptococcus agalactiae grown under conditions associated with neonatal exposure reveals the upregulation of the putative virulence factor C protein β antigenen_US
dc.status.refereedYesen_US
dc.date.Accepted2010-01-06
dc.date.application2010-02-04
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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