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dc.contributor.authorYang, Q.*
dc.contributor.authorZhang, M.*
dc.contributor.authorHarrington, Dean J.*
dc.contributor.authorBlack, G.W.*
dc.contributor.authorSutcliffe, I.C.*
dc.date.accessioned2017-03-08T12:16:13Z
dc.date.available2017-03-08T12:16:13Z
dc.date.issued2011-08
dc.identifier.citationYang Q, Zhang M, Harrington DJ et al (2011) A proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein β antigen and arginine deiminase. Microbes and Infection. 13(8-9): 757-760.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11568
dc.descriptionNoen_US
dc.description.abstractStreptococcus agalactiae is a major neonatal pathogen. Disease progression is characterised by bacterial adaptation from commensal maternal vaginal colonisation to environments associated with neonatal disease, including exposure to blood. To explore this adaptation in vitro, we have used proteomics to identify proteins differentially expressed following growth on Todd Hewitt agar in the presence or absence of 10% v/v human serum. Twelve differentially expressed proteins were identified. Notably, the C protein β antigen and arginine deiminase proteins were upregulated following growth in the presence of human serum, consistent with previous studies implicating these two proteins in the pathogenesis of S. agalactiae disease.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.micinf.2011.03.001en_US
dc.subjectC protein Beta antigen; Colonisation; Group B Streptococcus; Proteomics; Sepsis; Virulence factorsen_US
dc.titleA proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein β antigen and arginine deiminaseen_US
dc.status.refereedYesen_US
dc.date.Accepted2011-03-24
dc.date.application2011-03-31
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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