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    Part-time versus full-time occlusion therapy for treatment of amblyopia: A meta-analysis

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    Publication date
    2017
    Author
    Yazdani, N.
    Sadeghi, R.
    Momeni-Moghaddam, H.
    Zarifmahmoudi, L.
    Ehsaei, Asieh
    Barrett, Brendan T.
    Keyword
    Occlusion; Amblyopia; Part-time; Full-time
    Rights
    (c) 2017 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Purpose: To compare full-time occlusion (FTO) and part-time occlusion (PTO) therapy in the treatment of amblyopia, with the secondary aim of evaluating the minimum number of hours of part-time patching required for maximal effect from occlusion. Methods: A literature search was performed in PubMed, Scopus, Science Direct, Ovid, Web of Science and Cochrane library. Methodological quality of the literature was evaluated according to the Oxford Center for Evidence Based Medicine and modified Newcastle-Ottawa scale. Statistical analyses were performed using Comprehensive Meta-Analysis (version 2, Biostat Inc., USA). Results: The present meta-analysis included six studies (three randomized controlled trials [RCTs] and three non-RCTs). Pooled standardized difference in the mean changes in the visual acuity was 0.337 [lower and upper limits: 0.009, 0.683] higher in the FTO as compared to the PTO group; however, this difference was not statistically significant (P ¼ 0.056, Cochrane Q value ¼ 20.4 (P ¼ 0.001), I2 ¼ 75.49%). Egger's regression intercept was 5.46 (P ¼ 0.04). The pooled standardized difference in means of visual acuity changes was 1.097 [lower and upper limits: 0.68, 1.513] higher in the FTO arm (P < 0.001), and 0.7 [lower and upper limits: 0.315, 1.085] higher in the PTO arm (P < 0.001) compared to PTO less than two hours. Conclusions: This meta-analysis shows no statistically significant difference between PTO and FTO in treatment of amblyopia. However, our results suggest that the minimum effective PTO duration, to observe maximal improvement in visual acuity is six hours per day.
    URI
    http://hdl.handle.net/10454/11541
    Version
    Published version
    Citation
    Yazdani N, Sadeghi R, Momeni-Moghaddam H et al (2017) Part-time versus full-time occlusion therapy for treatment of amblyopia: A meta-analysis. Journal of Current Ophthalmology. 29(2): 76-84.
    Link to publisher’s version
    http://doi.org/10.1016/j.joco.2017.01.006
    Type
    Article
    Collections
    Life Sciences Publications

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