MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin
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Publication date
2014-10-28Author
Kalafatovic, D.Nobis, M.
Javid, Nadeem
Frederix, P.W.J.M.
Anderson, K.I.
Saunders, B.R.
Ulijn, R.V.
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(c) 2015 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)Peer-Reviewed
YesOpen Access status
openAccessAccepted for publication
2014-10-09
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Show full item recordAbstract
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.Version
Published versionCitation
Kalafatovic D, Nobis M, Javid N et al (2015) MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Sciences. 3(2): 246-249.Link to Version of Record
https://doi.org/10.1039/C4BM00297KType
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1039/C4BM00297K