Show simple item record

dc.contributor.authorFrederix, P.W.J.M.*
dc.contributor.authorScott, G.G.*
dc.contributor.authorAbul-Haija, Y.M.*
dc.contributor.authorKalafatovic, D.*
dc.contributor.authorPappas, C.G.*
dc.contributor.authorJavid, Nadeem*
dc.contributor.authorHunt, N.T.*
dc.contributor.authorUlijn, R.V.*
dc.contributor.authorTuttle, T.*
dc.date.accessioned2017-02-21T09:46:25Z
dc.date.available2017-02-21T09:46:25Z
dc.date.issued2015-01-05
dc.identifier.citationFrederix PWJM, Scott GG, Abul-Haija YM et al (2015) Exploring the Sequence Space for (tri-) Peptide Self-assembly to Design and Discover New Hydrogels. Nature Chemistry. 7: 30-37.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11423
dc.descriptionNoen_US
dc.description.abstractPeptides that self-assemble into nanostructures are of tremendous interest for biological, medical, photonic and nanotechnological applications. The enormous sequence space that is available from 20 amino acids probably harbours many interesting candidates, but it is currently not possible to predict supramolecular behaviour from sequence alone. Here, we demonstrate computational tools to screen for the aqueous self-assembly propensity in all of the 8,000 possible tripeptides and evaluate these by comparison with known examples. We applied filters to select for candidates that simultaneously optimize the apparently contradicting requirements of aggregation propensity and hydrophilicity, which resulted in a set of design rules for self-assembling sequences. A number of peptides were subsequently synthesized and characterized, including the first reported tripeptides that are able to form a hydrogel at neutral pH. These tools, which enable the peptide sequence space to be searched for supramolecular properties, enable minimalistic peptide nanotechnology to deliver on its promise.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1038/nchem.2122en_US
dc.subjectSelf-assembly; Tri-peptide; Hydrogelsen_US
dc.titleExploring the Sequence Space for (tri-) Peptide Self-assembly to Design and Discover New Hydrogelsen_US
dc.status.refereedYesen_US
dc.date.Accepted2014-10-28
dc.date.application2014-12-08
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


This item appears in the following Collection(s)

Show simple item record