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    Exploring the Sequence Space for (tri-) Peptide Self-assembly to Design and Discover New Hydrogels

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    Publication date
    2015-01-05
    Author
    Frederix, P.W.J.M.
    Scott, G.G.
    Abul-Haija, Y.M.
    Kalafatovic, D.
    Pappas, C.G.
    Javid, Nadeem
    Hunt, N.T.
    Ulijn, R.V.
    Tuttle, T.
    Keyword
    Self-assembly; Tri-peptide; Hydrogels
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Peptides that self-assemble into nanostructures are of tremendous interest for biological, medical, photonic and nanotechnological applications. The enormous sequence space that is available from 20 amino acids probably harbours many interesting candidates, but it is currently not possible to predict supramolecular behaviour from sequence alone. Here, we demonstrate computational tools to screen for the aqueous self-assembly propensity in all of the 8,000 possible tripeptides and evaluate these by comparison with known examples. We applied filters to select for candidates that simultaneously optimize the apparently contradicting requirements of aggregation propensity and hydrophilicity, which resulted in a set of design rules for self-assembling sequences. A number of peptides were subsequently synthesized and characterized, including the first reported tripeptides that are able to form a hydrogel at neutral pH. These tools, which enable the peptide sequence space to be searched for supramolecular properties, enable minimalistic peptide nanotechnology to deliver on its promise.
    URI
    http://hdl.handle.net/10454/11423
    Version
    No full-text in the repository
    Citation
    Frederix PWJM, Scott GG, Abul-Haija YM et al (2015) Exploring the Sequence Space for (tri-) Peptide Self-assembly to Design and Discover New Hydrogels. Nature Chemistry. 7: 30-37.
    Link to publisher’s version
    http://dx.doi.org/10.1038/nchem.2122
    Type
    Article
    Collections
    Life Sciences Publications

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