Show simple item record

dc.contributor.authorAitipamula, S.
dc.contributor.authorVangala, Venu R.
dc.date.accessioned2017-02-21T09:21:49Z
dc.date.available2017-02-21T09:21:49Z
dc.date.issued2017
dc.identifier.citationAitipamula S and Vangala VR (2017) X-ray crystallography and its role in understanding physicochemical properties of pharmaceutical cocrystals. Journal of the Indian Institute of Science. 97(2): 227-243.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11421
dc.descriptionYesen_US
dc.description.abstractProperties of a matter are intrinsically dependent upon the internal arrangement of molecules in the solid state. Therefore, knowledge of 3-dimensional structure of the matter is prerequisite for structure-property correlations and design of functional materials. Over the past century, X-ray crystallography has evolved as a method of choice for accurate determination of molecular structure at atomic resolution. The structural information obtained from crystallographic analysis paved the way for rapid development in electronic devices, mineralogy, geosciences, materials science, pharmaceuticals, etc. Knowledge of the structural information of active pharmaceutical ingredients (APIs) is prerequisite for rational drug design and synthesis of new chemical entities for development as new medicines. Over the past two decades, X-ray crystallography has played a key role in the design of pharmaceutical cocrystals-crystalline solids containing an API and one or more of pharmaceutically acceptable coformers. These materials have proved promising for fine-tuning several important properties of APIs. This short review highlights the history of crystallography, early breakthroughs, and the role of crystallography in understanding physicochemical properties of pharmaceutical cocrystals.en_US
dc.description.sponsorshipS. Aitipamula gratefully acknowledges the financial support from the Institute of Chemical and Engineering Sciences of A*STAR (Agency for Science, Technology and Research), Singapore. V. R. Vangala thanks Royal Society of Chemistry for Researcher Mobility Grant (2015/17).en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/ 10.1007/s41745-017-0026-4
dc.rights© 2017 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (https://creativecommons.org/licenses/by/4.0/legalcode)en_US
dc.subjectX-ray crystallography; Active pharmaceutical ingredients (APIs); Pharmaceutical cocrystals-crystalline solids; Physicochemical properties of pharmaceutical cocrystalsen_US
dc.titleX-ray crystallography and its role in understanding physicochemical properties of pharmaceutical cocrystalsen_US
dc.status.refereedYesen_US
dc.date.Accepted2017-02-07
dc.date.application2017-05-29
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-27T01:14:47Z


Item file(s)

Thumbnail
Name:
Vangala_et_al_JIISc.pdf
Size:
1.314Mb
Format:
PDF
Description:
To keep suppressed
Thumbnail
Name:
Vangala_JIIS.pdf
Size:
1.403Mb
Format:
PDF
Description:
Keep suppressed - accepted ...
Thumbnail
Name:
aitimapula_et_al_2017.pdf
Size:
3.079Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record