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dc.contributor.authorKantamneni, Sriharsha*
dc.date.accessioned2017-02-17T10:08:35Z
dc.date.available2017-02-17T10:08:35Z
dc.date.issued2016-12-20
dc.identifier.citationKantamneni S (2016) Modulation of Neurotransmission by the GABAB Receptor. In: Colombo G (ed) GABAB Receptor. The Receptors [series] vol 29. Basel: Springer International Publishing AG. pp 109-128.
dc.identifier.urihttp://hdl.handle.net/10454/11400
dc.descriptionNo
dc.description.abstractMost inhibitory signals are mediated via γ-aminobutyric acid (GABA) receptors whereas glutamate receptors mediate most excitatory signals (Trends Neurosci 14:515–519, 1991; Annu Rev Neurosci 17:31–108, 1994). Many factors influence the regulation of excitatory and inhibitory synaptic inputs on a given neuron. One important factor is the subtype of neurotransmitter receptor present not only at the correct location to receive the appropriate signals but also their abundance at synapses (Pharmacol Rev 51: 7–61, 1999; Cold Spring Harb Perspect Biol 3, 2011). GABAB receptors are G-protein-coupled receptors and different subunits dimerise to form a functional receptor. GABAB receptor subunits are widely expressed in the brain and by assembling different isoform combinations and accessory proteins they produce variety of physiological and pharmacological profiles in mediating both inhibitory and excitatory neurotransmission. This chapter will describe the understanding of the molecular mechanisms underlying GABAB receptor regulation of glutamate and GABAA receptors and how they modulate excitatory and inhibitory neurotransmission.
dc.language.isoen
dc.subjectGABAB receptor
dc.subjectGlutamate receptor
dc.subjectGPCR
dc.subjectNeurotransmission
dc.subjectCross-talk
dc.subjectAKAP
dc.subjectExcitation Inhibition
dc.titleModulation of Neurotransmission by the GABAB Receptor
dc.status.refereedYes
dc.typeBook chapter
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1007/978-3-319-46044-4_7
dc.openaccess.statusclosedAccess


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