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dc.contributor.authorKantamneni, Sriharsha*
dc.date.accessioned2017-02-17T10:08:35Z
dc.date.available2017-02-17T10:08:35Z
dc.date.issued2016-12-20
dc.identifier.citationKantamneni S (2016) Modulation of Neurotransmission by the GABAB Receptor. In: Colombo G (ed) GABAB Receptor. The Receptors [series] vol 29. Basel: Springer International Publishing AG. pp 109-128.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11400
dc.descriptionnoen_US
dc.description.abstractMost inhibitory signals are mediated via γ-aminobutyric acid (GABA) receptors whereas glutamate receptors mediate most excitatory signals (Trends Neurosci 14:515–519, 1991; Annu Rev Neurosci 17:31–108, 1994). Many factors influence the regulation of excitatory and inhibitory synaptic inputs on a given neuron. One important factor is the subtype of neurotransmitter receptor present not only at the correct location to receive the appropriate signals but also their abundance at synapses (Pharmacol Rev 51: 7–61, 1999; Cold Spring Harb Perspect Biol 3, 2011). GABAB receptors are G-protein-coupled receptors and different subunits dimerise to form a functional receptor. GABAB receptor subunits are widely expressed in the brain and by assembling different isoform combinations and accessory proteins they produce variety of physiological and pharmacological profiles in mediating both inhibitory and excitatory neurotransmission. This chapter will describe the understanding of the molecular mechanisms underlying GABAB receptor regulation of glutamate and GABAA receptors and how they modulate excitatory and inhibitory neurotransmission.en_US
dc.language.isoenen_US
dc.subjectGABAB receptor; Glutamate receptor; GPCR; Neurotransmission; Cross-talk; AKAP; Excitation Inhibitionen_US
dc.titleModulation of Neurotransmission by the GABAB Receptoren_US
dc.status.refereedyesen_US
dc.typeBook chapteren_US
dc.type.versionNo full-text in the repositoryen_US
dc.identifier.doihttps://doi.org/10.1007/978-3-319-46044-4_7


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