Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis
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KeywordsEx vivo cornea; Microbial keratitis; Colony-forming units; Corneal model
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In the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell communication of in vivo models. Here, we propose reproducible ex vivo models of single- and dual-infection keratitis as an alternative to in vivo and in vitro models.