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dc.contributor.authorPlenderleith, R.A.*
dc.contributor.authorPateman, C.J.*
dc.contributor.authorRodenburg, C.*
dc.contributor.authorHaycock, J.W.*
dc.contributor.authorClaeyssens, F.*
dc.contributor.authorSammon, C.*
dc.contributor.authorRimmer, Stephen*
dc.date.accessioned2017-02-15T14:03:24Z
dc.date.available2017-02-15T14:03:24Z
dc.date.issued2015
dc.identifier.citationPlenderleith RA, Pateman CJ, Rodenburgh C et al (2015) Arginine–glycine–aspartic acid functional branched semi-interpenetrating hydrogels. Soft Matter. 11(38): 7567-7578.en_US
dc.identifier.urihttp://hdl.handle.net/10454/11365
dc.descriptionYesen_US
dc.description.abstractFor the first time a series of functional hydrogels based on semi-interpenetrating networks with both branched and crosslinked polymer components have been prepared and we show the successful use of these materials as substrates for cell culture. The materials consist of highly branched poly(N-isopropyl acrylamide)s with peptide functionalised end groups in a continuous phase of crosslinked poly(vinyl pyrrolidone). Functionalisation of the end groups of the branched polymer component with the GRGDS peptide produces a hydrogel that supports cell adhesion and proliferation. The materials provide a new synthetic functional biomaterial that has many of the features of extracellular matrix, and as such can be used to support tissue regeneration and cell culture. This class of high water content hydrogel material has important advantages over other functional hydrogels in its synthesis and does not require post-processing modifications nor are functional-monomers, which change the polymerisation process, required. Thus, the systems are amenable to large scale and bespoke manufacturing using conventional moulding or additive manufacturing techniques. Processing using additive manufacturing is exemplified by producing tubes using microstereolithography.en_US
dc.description.sponsorshipEPSRCen_US
dc.language.isoenen_US
dc.rights(c) 2015 The Authors. This Open Access article is licensed under a Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)en_US
dc.subjectBranched polymers; Hydrogels; GRGDS; Cell adhesionen_US
dc.titleArginine-glycine-aspartic acid functional branched semi-interpenetrating hydrogelsen_US
dc.status.refereedYesen_US
dc.date.Accepted2015-08-10
dc.date.application2015-08-11
dc.typeArticleen_US
dc.type.versionPublished versionen_US
dc.identifier.doihttps://doi.org/10.1039/C5SM00695C
refterms.dateFOA2018-07-26T09:23:31Z


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