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dc.contributor.authorPlenderleith, R.A.*
dc.contributor.authorPateman, C.J.*
dc.contributor.authorRodenburg, C.*
dc.contributor.authorHaycock, J.W.*
dc.contributor.authorClaeyssens, F.*
dc.contributor.authorSammon, C.*
dc.contributor.authorRimmer, Stephen*
dc.date.accessioned2017-02-15T14:03:24Z
dc.date.available2017-02-15T14:03:24Z
dc.date.issued2015
dc.identifier.citationPlenderleith RA, Pateman CJ, Rodenburgh C et al (2015) Arginine–glycine–aspartic acid functional branched semi-interpenetrating hydrogels. Soft Matter. 11(38): 7567-7578.
dc.identifier.urihttp://hdl.handle.net/10454/11365
dc.descriptionYes
dc.description.abstractFor the first time a series of functional hydrogels based on semi-interpenetrating networks with both branched and crosslinked polymer components have been prepared and we show the successful use of these materials as substrates for cell culture. The materials consist of highly branched poly(N-isopropyl acrylamide)s with peptide functionalised end groups in a continuous phase of crosslinked poly(vinyl pyrrolidone). Functionalisation of the end groups of the branched polymer component with the GRGDS peptide produces a hydrogel that supports cell adhesion and proliferation. The materials provide a new synthetic functional biomaterial that has many of the features of extracellular matrix, and as such can be used to support tissue regeneration and cell culture. This class of high water content hydrogel material has important advantages over other functional hydrogels in its synthesis and does not require post-processing modifications nor are functional-monomers, which change the polymerisation process, required. Thus, the systems are amenable to large scale and bespoke manufacturing using conventional moulding or additive manufacturing techniques. Processing using additive manufacturing is exemplified by producing tubes using microstereolithography.
dc.description.sponsorshipEPSRC
dc.language.isoen
dc.rights(c) 2015 The Authors. This Open Access article is licensed under a Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)
dc.subjectBranched polymers
dc.subjectHydrogels
dc.subjectGRGDS
dc.subjectCell adhesion
dc.titleArginine-glycine-aspartic acid functional branched semi-interpenetrating hydrogels
dc.status.refereedYes
dc.date.Accepted2015-08-10
dc.date.application2015-08-11
dc.typeArticle
dc.type.versionPublished version
dc.identifier.doihttps://doi.org/10.1039/C5SM00695C
dc.rights.licenseCC-BY
refterms.dateFOA2018-07-26T09:23:31Z
dc.openaccess.statusopenAccess


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