Arene ruthenium dithiolato-carborane complexes for boron neutron capture theory (BNCT)
| dc.contributor.author | Romero-Canelón, I. | * |
| dc.contributor.author | Phoenix, B. | * |
| dc.contributor.author | Pitto-Barry, Anaïs | * |
| dc.contributor.author | Tran, J. | * |
| dc.contributor.author | Soldevila-Barreda, Joan J. | * |
| dc.contributor.author | Kirby, N. | * |
| dc.contributor.author | Green, S. | * |
| dc.contributor.author | Sadler, P.J. | * |
| dc.contributor.author | Barry, Nicolas P.E. | * |
| dc.date.accessioned | 2017-01-31T12:48:09Z | |
| dc.date.available | 2017-01-31T12:48:09Z | |
| dc.date.issued | 2015 | |
| dc.identifier.citation | Romero-Canelón I, Phoenix B, Pitto-Barry A et al (2015) Arene ruthenium dithiolato-carborane complexes for boron neutron capture theory (BNCT). Journal of Organometallic Chemistry. 796: 17-25. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10454/11232 | |
| dc.description | Yes | en_US |
| dc.description.abstract | We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolatoecarborane complex [Ru(p-cymene) (1,2- dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 coreeshell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 mM and 0.17 mM, respectively) and cisplatinresistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 mM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5 ), and was sensitive to neutron irradiation in A2780 cells (1.4 more potent upon irradiation compared to non-irradiation). | en_US |
| dc.description.sponsorship | We thank the Leverhulme Trust (Early Career Fellowship No. ECF-2013-414 to NPEB), the University of Warwick (Grant No. RD14102 to NPEB), the University of Birmingham/EPSRC Follow-on- Fund (Grant No UOBFOF026 to BP), the ERC (Grant No. 247450 to PJS), EPSRC (EP/F034210/1 to PJS). | en_US |
| dc.language.iso | en | en_US |
| dc.relation.isreferencedby | http://dx.doi.org/10.1016/j.jorganchem.2015.05.011 | en_US |
| dc.rights | © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ). | en_US |
| dc.subject | Arene ruthenium; Carborane; Pluronic; Micelles; Boron neutron capture therapy | en_US |
| dc.title | Arene ruthenium dithiolato-carborane complexes for boron neutron capture theory (BNCT) | en_US |
| dc.status.refereed | Yes | en_US |
| dc.date.Accepted | 2015-05-08 | |
| dc.date.application | 2015-05-18 | |
| dc.type | Article | en_US |
| dc.type.version | Published version | en_US |
| refterms.dateFOA | 2018-07-26T09:44:12Z |
